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- W2079706088 endingPage "23" @default.
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- W2079706088 abstract "Upon DNA damage, p53 has been shown to be modified at a number of N-terminal phosphorylation sites including Ser15 and -33. Here we show that phosphorylation is induced as well at a novel site, Ser20. Phosphorylation at Ser15, -20 and -33 can occur within minutes of DNA damage. Interestingly, while the DNA-binding activities of p53 appear to be dispensable, efficient phosphorylation at these three sites requires the tetramerization domain of p53. Substitution of an artificial tetramerization domain for this region also permits phosphorylation at the N-terminus, suggesting that oligomerization is important for DNA damage-induced signalling to p53." @default.
- W2079706088 created "2016-06-24" @default.
- W2079706088 creator A5047997260 @default.
- W2079706088 creator A5065604656 @default.
- W2079706088 creator A5080267048 @default.
- W2079706088 date "1999-04-01" @default.
- W2079706088 modified "2023-09-27" @default.
- W2079706088 title "DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization." @default.
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- W2079706088 doi "https://doi.org/10.1093/emboj/18.7.1815" @default.
- W2079706088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171267" @default.
- W2079706088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10202145" @default.
- W2079706088 hasPublicationYear "1999" @default.
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