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- W2079706229 abstract "Previous studies have demonstrated that normal intact red blood cells (RBC's) will undergo membrane lipid peroxidation and will hemolyze in vitro in the presence of ASA+H2O2 but not with either agent alone (Ped. Res. 9:326, 1975). In order to determine whether ASA+H2O2 induced oxidant injury results in RBC membrane protein damage, 5% RBC suspensions were incubated with equal volumes of buffer, ASA (25 mg%), H2O2 (1.2%) or ASA (25 mg%)+ H2O2 (1.2%). Following incubation, RBC membrane proteins were separated on SDS gel. ASA+H2O2 resulted in the production of a high M. Wgt. membrane protein complex (M. Wgt. 300,000-600,000) with a decrease in other membrane protein fractions. Similar changes were not observed with ASA alone or H2O2 alone. Incubation with 14C-acetyl and 14C-carboxyl tagged ASA+H2O2 failed to label any membrane protein fraction. Although prior incubation with water soluble ≥ tocopherol in concentrations as low as 0.01 mg/ml completely prevented hemolysis and membrane lipid peroxidation in the presence of ASA+H2O2, no protective effect on RBC membrane protein was found. While in this system lipid peroxidation is more predictive of in vitro hemolysis than is the membrane protein change, such protein change, if it were to occur in vivo, might result in hemolysis. ASA+H2O2 induced hemolysis represents an interesting model by which to study the multiple effects of oxidative damage on the normal intact RBC and the mechanism of the protection afforded by antioxidants." @default.
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- W2079706229 date "1978-04-01" @default.
- W2079706229 modified "2023-09-25" @default.
- W2079706229 title "662 ASPIRIN (ASA) AND HYDROGEN PEROXIDE (H2O2) INDUCED RED BLOOD CELL INJURY, MEMBRANE PROTEIN ALTERATIONS" @default.
- W2079706229 doi "https://doi.org/10.1203/00006450-197804001-00667" @default.
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