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• W207971186 abstract "During pregnancy some cells traffic between the fetus and mother and recent studies indicate low levels persist in the respective hosts decades later. Microchimerism (Mc) refers to a small population of cells or DNA harbored by one individual that derive from a genetically distinct individual. Persistent Mc can also arise from cell transfer between twins in utero or after a blood transfusion. Because women are preferentially affected by autoimmune disease, often with an increased incidence in post-reproductive years, fetal Mc has been investigated in diseases such as systemic sclerosis (SSc), autoimmune thyroiditis, primary biliary cirrhosis, Sjogren’s syndrome and systemic lupus erythematosus. Maternal Mc has been investigated in SSc, myositis and neonatal lupus. Evidence implicating fetal Mc is strongest in SSc where quantitatively higher levels of fetal Mc have been found and particular human leukocyte antigen (HLA) relationships of mother and child are associated with increased risk of subsequent SSc in the mother. Maternal Mc is implicated in myositis and neonatal lupus. It is unknown how Mc might be involved in autoimmune disease. Mc could play a role in the effector arm of immune responses either directly or indirectly. Microchimeric cells could be targets of an immune response, an intriguing possibility suggested by a recent study in which maternal cells identified in hearts of infants with neonatal lupus congenital heart block were predominantly cardiac myocytes. Alternatively microchimeric cells could be recruited secondarily to diseased tissues and function in tissue repair. The long-term consequences of naturally acquired Mc deriving from pregnancy are not yet known. Because persistent fetal and maternal Mc are not uncommon in healthy individuals it seems likely that beneficial effects may also accrue to the host. Recent advances in this active frontier of scientific research are discussed." @default.
• W207971186 created "2016-06-24" @default.
• W207971186 creator A5031506656 @default.
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• W207971186 date "2013-01-01" @default.
• W207971186 modified "2023-09-24" @default.
• W207971186 title "Bi-Directional Cell Trafficking During Pregnancy: Long-term Consequences for Human Health" @default.
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