FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079712957> ?p ?o ?g. }

• W2079712957 endingPage "2135" @default.
• W2079712957 startingPage "2125" @default.
• W2079712957 abstract "A-Kinase Anchoring Proteins (AKAPs) direct the flow of cellular information by positioning multiprotein signaling complexes into proximity with effector proteins. However, certain AKAPs are not stationary but can undergo spatiotemporal redistribution in response to stimuli. Gravin, a 300kD AKAP that intersects with a diverse signaling array, is localized to the plasma membrane but has been shown to translocate to the cytosol following the elevation of intracellular calcium ([Ca(2+)]i). Despite the potential for gravin redistribution to impact multiple signaling pathways, the dynamics of this event remain poorly understood. In this study, quantitative microscopy of cells expressing gravin-EGFP revealed that Ca(2+) elevation caused the complete translocation of gravin from the cell cortex to the cytosol in as little as 60s of treatment with ionomycin or thapsigargin. In addition, receptor mediated signaling was also shown to cause gravin redistribution following ATP treatment, and this event required both [Ca(2+)]i elevation and PKC activation. To understand the mechanism for Ca(2+) mediated gravin dynamics, deletion of calmodulin-binding domains revealed that a fourth putative calmodulin binding domain called CB4 (a.a. 670-694) is critical for targeting gravin to the cell cortex despite its location downstream of gravin's membrane-targeting domains, which include an N-terminal myristoylation site and three polybasic domains. Finally, confocal microscopy of cells co-transfected with gravin-EYFP and PKA RII-ECFP revealed that gravin redistribution mediated by ionomycin, thapsigargin, and ATP each triggered the gravin-dependent loss of PKA localized at the cell cortex. Our results support the hypothesis that gravin redistribution regulates cross-talk between PKA-dependent signaling and receptor-mediated events involving Ca(2+) and PKC." @default.
• W2079712957 created "2016-06-24" @default.
• W2079712957 creator A5045565015 @default.
• W2079712957 creator A5063436035 @default.
• W2079712957 date "2013-11-01" @default.
• W2079712957 modified "2023-09-23" @default.
• W2079712957 title "Receptor-mediated Ca2+ and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin" @default.
• W2079712957 cites W1496980490 @default.
• W2079712957 cites W1593385535 @default.
• W2079712957 cites W1973119847 @default.
• W2079712957 cites W1973750090 @default.
• W2079712957 cites W1983449340 @default.
• W2079712957 cites W1996290332 @default.
• W2079712957 cites W1998510219 @default.
• W2079712957 cites W2011092125 @default.
• W2079712957 cites W2012370766 @default.
• W2079712957 cites W2020645222 @default.
• W2079712957 cites W2029017148 @default.
• W2079712957 cites W2043804549 @default.
• W2079712957 cites W2053377460 @default.
• W2079712957 cites W2058386132 @default.
• W2079712957 cites W2079364883 @default.
• W2079712957 cites W2079565601 @default.
• W2079712957 cites W2082637975 @default.
• W2079712957 cites W2090576076 @default.
• W2079712957 cites W2092455126 @default.
• W2079712957 cites W2093646166 @default.
• W2079712957 cites W2095354443 @default.
• W2079712957 cites W2101108802 @default.
• W2079712957 cites W2102424174 @default.
• W2079712957 cites W2120385383 @default.
• W2079712957 cites W2120904086 @default.
• W2079712957 cites W2123496888 @default.
• W2079712957 cites W2127172867 @default.
• W2079712957 cites W2135262062 @default.
• W2079712957 cites W2137211481 @default.
• W2079712957 cites W2137500801 @default.
• W2079712957 cites W2142329875 @default.
• W2079712957 cites W2151218508 @default.
• W2079712957 cites W2153106282 @default.
• W2079712957 cites W2169067272 @default.
• W2079712957 cites W2326521810 @default.
• W2079712957 cites W267614173 @default.
• W2079712957 cites W4241382046 @default.
• W2079712957 doi "https://doi.org/10.1016/j.cellsig.2013.07.004" @default.
• W2079712957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3796772" @default.
• W2079712957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23838009" @default.
• W2079712957 hasPublicationYear "2013" @default.
• W2079712957 type Work @default.
• W2079712957 sameAs 2079712957 @default.
• W2079712957 citedByCount "11" @default.
• W2079712957 countsByYear W20797129572014 @default.
• W2079712957 countsByYear W20797129572015 @default.
• W2079712957 countsByYear W20797129572016 @default.
• W2079712957 countsByYear W20797129572018 @default.
• W2079712957 countsByYear W20797129572019 @default.
• W2079712957 countsByYear W20797129572020 @default.
• W2079712957 crossrefType "journal-article" @default.
• W2079712957 hasAuthorship W2079712957A5045565015 @default.
• W2079712957 hasAuthorship W2079712957A5063436035 @default.
• W2079712957 hasBestOaLocation W20797129572 @default.
• W2079712957 hasConcept C12554922 @default.
• W2079712957 hasConcept C181199279 @default.
• W2079712957 hasConcept C185592680 @default.
• W2079712957 hasConcept C190062978 @default.
• W2079712957 hasConcept C2776989580 @default.
• W2079712957 hasConcept C2777146706 @default.
• W2079712957 hasConcept C29688787 @default.
• W2079712957 hasConcept C55493867 @default.
• W2079712957 hasConcept C62478195 @default.
• W2079712957 hasConcept C79879829 @default.
• W2079712957 hasConcept C86803240 @default.
• W2079712957 hasConcept C95444343 @default.
• W2079712957 hasConcept C98539663 @default.
• W2079712957 hasConceptScore W2079712957C12554922 @default.
• W2079712957 hasConceptScore W2079712957C181199279 @default.
• W2079712957 hasConceptScore W2079712957C185592680 @default.
• W2079712957 hasConceptScore W2079712957C190062978 @default.
• W2079712957 hasConceptScore W2079712957C2776989580 @default.
• W2079712957 hasConceptScore W2079712957C2777146706 @default.
• W2079712957 hasConceptScore W2079712957C29688787 @default.
• W2079712957 hasConceptScore W2079712957C55493867 @default.
• W2079712957 hasConceptScore W2079712957C62478195 @default.
• W2079712957 hasConceptScore W2079712957C79879829 @default.
• W2079712957 hasConceptScore W2079712957C86803240 @default.
• W2079712957 hasConceptScore W2079712957C95444343 @default.
• W2079712957 hasConceptScore W2079712957C98539663 @default.
• W2079712957 hasIssue "11" @default.
• W2079712957 hasLocation W20797129571 @default.
• W2079712957 hasLocation W20797129572 @default.
• W2079712957 hasLocation W20797129573 @default.
• W2079712957 hasLocation W20797129574 @default.
• W2079712957 hasOpenAccess W2079712957 @default.
• W2079712957 hasPrimaryLocation W20797129571 @default.
• W2079712957 hasRelatedWork W1985189445 @default.
• W2079712957 hasRelatedWork W1993707289 @default.
• W2079712957 hasRelatedWork W2059104701 @default.
• W2079712957 hasRelatedWork W2069099188 @default.

• next