Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079714466> ?p ?o ?g. }
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- W2079714466 startingPage "592" @default.
- W2079714466 abstract "Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of biological processes. To almost all organisms, iron is both essential and potentially toxic, where homeostatic concentrations must be stringently maintained. Within the iron-restricted host, the survival and proliferation of microbial invaders is contingent upon exploiting the host iron pool. Bacteria express a multitude of complex, and often redundant means of acquiring iron, including surface-associated heme-uptake pathways, high affinity iron-scavenging siderophores and transporters of free inorganic iron. Within the last decade, our understanding of iron acquisition by Gram-positive pathogens has expanded substantively, from the discovery of the iron-regulated surface-determinant pathway and numerous unique siderophores through to the detailed elucidation of heme–iron extraction, and heme and siderophore coordination and transfer. This review provides a comprehensive summary of the iron acquisition strategies of notorious Gram-positive pathogens and highlights how both conserved and distinct tactics for acquiring iron contribute to the pathophysiology of these bacteria. Further, a focus on recent structural and mechanistic studies details how these iron acquisition systems may be exploited in the development of novel therapeutics." @default.
- W2079714466 created "2016-06-24" @default.
- W2079714466 creator A5005827160 @default.
- W2079714466 creator A5010986892 @default.
- W2079714466 date "2015-04-09" @default.
- W2079714466 modified "2023-10-16" @default.
- W2079714466 title "Recent developments in understanding the iron acquisition strategies of gram positive pathogens" @default.
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