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- W2079715481 abstract "1. Camitine esters of erucic acid (22:1 n-9 cis), cetoleic acid (22:1 n-11 cis), brassidic acid (22 : 1 n-9 trans), gadoleic acid (20 : 1 n-9 cis) and oleic acid (18 : 1 n-9 cis) have been compared as mitochondrial substrates and as inhibitors of palmitoylcarnitine oxidation in heart and liver mitochondria. 2. Both the rate of intramitochondrial-CoA acylation and the rate of β-oxidation decreases as the chain length increases from C18 to C22. There are no significant differences among the three C22 isomers as oxidizable substrates. 3. All the tested acylcamitines inhibit palmitoylcarnitine oxidation. The C18 and C20 acylcarnitines inhibit by virtue of being competing substrates; i.e. the respiration is not inhibited. The C22-isomers inhibit also respiration; this shows that the inhibition of palmitoylcarnitine oxidation is not compensated for by oxidation of C22-acylcarnitines. Brassidoylcamitine inhibits the oxidation of palmitoylcarnitine and respiration less than erucoyl- and cetoleoylcarnitine. The different behaviour of the C22-isomers is probably due to the difference in their competitive properties with respect to long-chain acyl-CoA dehydrogenase. 4. All C22 acylcamitines seem to be relatively better oxidized in the liver than in the heart mitochondria while their inhibitory effect on the usage of the radioactive palmitoylcarnitine is very similar. 5. Palmitoylcarnitine inhibits almost completely the “endogenous” formation of acetyl-CoA presumably from malate via pyruvate in the liver mitochondria while the C22-acylcarnitines cause only a partial inhibiton of this acetyl-CaO formation." @default.
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- W2079715481 title "Monoethylenic C20 and C22fatty acids in marine oil and rapeseed oil. studies on their oxidation and on their relative ability to inhibit palmitate oxidation in heart and liver mitochondria" @default.
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- W2079715481 doi "https://doi.org/10.1016/0005-2760(77)90041-8" @default.
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