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- W2079715515 abstract "Neuropsychiatric symptoms, previously denominated as behavioural and psychological symptoms of dementia, are common features of Alzheimer's disease (AD) and are one of the major risk factors for institutionalization. At present, the role of the apolipoprotein E (APOE) gene in the development of neuropsychiatric symptoms in AD patients is unclear. In this paper, we summarized the findings of the studies of neuropsychiatric symptoms and neuropsychiatric syndromes/endophenotypes in AD in relation to APOE genotypes, with special attention to the possible underlying mechanisms. While some studies failed to find a significant association between APOE and neuropsychiatric symptoms in late-onset AD, other studies reported a significant association between the APOE ε4 allele and an increase in agitation/aggression, hallucinations, delusions, and late-life depression or anxiety. Furthermore, some negative studies that focused on the distribution of APOE genotypes between AD patients with or without neuropsychiatric symptoms further emphasized the importance of subgrouping neuropsychiatric symptoms in distinct neuropsychiatric syndromes. Explanations for the variable findings in the existing studies included differences in patient populations, differences in the assessment of neuropsychiatric symptomatology, and possible lack of statistical power to detect associations in the negative studies." @default.
- W2079715515 created "2016-06-24" @default.
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- W2079715515 creator A5090889863 @default.
- W2079715515 date "2011-01-01" @default.
- W2079715515 modified "2023-10-10" @default.
- W2079715515 title "Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene" @default.
- W2079715515 cites W131511574 @default.
- W2079715515 cites W1476312560 @default.
- W2079715515 cites W1564703693 @default.
- W2079715515 cites W1590095886 @default.
- W2079715515 cites W1598879945 @default.
- W2079715515 cites W1688235741 @default.
- W2079715515 cites W1770880387 @default.
- W2079715515 cites W1867505698 @default.
- W2079715515 cites W1964503009 @default.
- W2079715515 cites W1966194104 @default.
- W2079715515 cites W1966283817 @default.
- W2079715515 cites W1966481650 @default.
- W2079715515 cites W1968183885 @default.
- W2079715515 cites W1974191027 @default.
- W2079715515 cites W1976693912 @default.
- W2079715515 cites W1981934993 @default.
- W2079715515 cites W1984477821 @default.
- W2079715515 cites W1984737558 @default.
- W2079715515 cites W1988767039 @default.
- W2079715515 cites W1990172803 @default.
- W2079715515 cites W1992488190 @default.
- W2079715515 cites W1993974844 @default.
- W2079715515 cites W1996567609 @default.
- W2079715515 cites W2000954930 @default.
- W2079715515 cites W2001688761 @default.
- W2079715515 cites W2006532470 @default.
- W2079715515 cites W2010202486 @default.
- W2079715515 cites W2011508284 @default.
- W2079715515 cites W2014247959 @default.
- W2079715515 cites W2014784504 @default.
- W2079715515 cites W2020758205 @default.
- W2079715515 cites W2023506257 @default.
- W2079715515 cites W2027447311 @default.
- W2079715515 cites W2027456333 @default.
- W2079715515 cites W2028856132 @default.
- W2079715515 cites W2030689331 @default.
- W2079715515 cites W2030832792 @default.
- W2079715515 cites W2031505047 @default.
- W2079715515 cites W2033550928 @default.
- W2079715515 cites W2035020452 @default.
- W2079715515 cites W2035289743 @default.
- W2079715515 cites W2036798392 @default.
- W2079715515 cites W2037743877 @default.
- W2079715515 cites W2038431116 @default.
- W2079715515 cites W2043297459 @default.
- W2079715515 cites W2044392105 @default.
- W2079715515 cites W2045453193 @default.
- W2079715515 cites W2045880509 @default.
- W2079715515 cites W2047397116 @default.
- W2079715515 cites W2047546856 @default.
- W2079715515 cites W2052261143 @default.
- W2079715515 cites W2052367344 @default.
- W2079715515 cites W2054546547 @default.
- W2079715515 cites W2058116753 @default.
- W2079715515 cites W2059765642 @default.
- W2079715515 cites W2063135482 @default.
- W2079715515 cites W2068175655 @default.
- W2079715515 cites W2068441330 @default.
- W2079715515 cites W2069196876 @default.
- W2079715515 cites W2069238604 @default.
- W2079715515 cites W2071261456 @default.
- W2079715515 cites W2072150523 @default.
- W2079715515 cites W2072737252 @default.
- W2079715515 cites W2075330375 @default.
- W2079715515 cites W2076072757 @default.
- W2079715515 cites W2077067029 @default.
- W2079715515 cites W2077955123 @default.
- W2079715515 cites W2078242829 @default.
- W2079715515 cites W2079517191 @default.
- W2079715515 cites W2080831516 @default.
- W2079715515 cites W2081138810 @default.
- W2079715515 cites W2081872165 @default.
- W2079715515 cites W2083020792 @default.
- W2079715515 cites W2085013652 @default.
- W2079715515 cites W2085054482 @default.
- W2079715515 cites W2085510532 @default.
- W2079715515 cites W2085686969 @default.
- W2079715515 cites W2086389643 @default.
- W2079715515 cites W2088317481 @default.
- W2079715515 cites W2088361570 @default.
- W2079715515 cites W2089974109 @default.
- W2079715515 cites W2090233853 @default.
- W2079715515 cites W2092129469 @default.
- W2079715515 cites W2092767820 @default.
- W2079715515 cites W2095132657 @default.
- W2079715515 cites W2097885652 @default.