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- W2079716448 abstract "ObjectivesTo assess the value of first trimester scanning for the diagnosis of structural and chromosomal abnormalities.Population/methodsAn unselected group of 7447 pregnant women who had a first trimester scan in our unit. In all the cases an anatomical survey was performed and the nuchal translucency was measured. Four thousand and 84 women also had second trimester biochemical screening. We assessed the performance of first trimester scanning in the detection of structural and chromosomal abnormalities.ResultsThe incidence of anomalous fetuses was 1.4%, including 43 chromosomal abnormalities. The detection rate for structural abnormalities was 59% (37/63). Seventy-eight percent of chromosomal abnormalities were diagnosed at 11–14 weeks either because of a nuchal translucency measurement above the 99th centile or due to the presence of structural abnormalities. Second trimester biochemical screening detected half of the fetuses with trisomy 21 which were missed by first trimester screening, increasing the sensitivity to 90.5% (19/21; 95%C.I. 69.6% to 98.8%). However, the positive predictive value of the biochemical test was very low (0.5%).ConclusionFirst trimester NT measurement is an effective screening test for the prenatal detection of fetuses with structural and chromosomal abnormalities. Although the measurement of biochemical markers in the second trimester can detect additional affected fetuses this may be out-weighted by the delay in diagnosis, the extra visits and cost so that the right time for biochemical screening still needs to be determined. Second trimester anomaly scanning should continue to be an essential part of a prenatal screening programme." @default.
- W2079716448 created "2016-06-24" @default.
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- W2079716448 date "2000-10-01" @default.
- W2079716448 modified "2023-09-25" @default.
- W2079716448 title "WS16: Early pregnancy WS16-01The value of first trimester sonography for the diagnosis of structural and chromosomal abnormalities" @default.
- W2079716448 doi "https://doi.org/10.1046/j.1469-0705.2000.00009-1-102.x" @default.
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