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• W2079717800 abstract "A dominant T cell population bearing the cross-reactive idiotype of T cell antigen receptor (TcR) has been obtained using an anti-TcR monoclonal antibody (mAb) developed in syngeneic mice. Forty-four cytotoxic T cell (CTL) clones with reactivity to a mAb (N9 127) were selected out of 396 H-2Db-restricted CTL clones specific for FBL-3 tumor antigen from C57BL/6 mice. These CTL clones were divided into two groups according to the blocking pattern of cytotoxic activities with mAb N9-127. All eight CTL clones chosen from both groups expressed TcR with a specific combination of α and β chains (Vα1Jα112-2/Vβ10Dβ2.1Jβ2.7), and the difference in the blocking susceptibility resided in a single amino acid substitution (Gly to Asp) in the D-J joint of β chain. This provides direct evidence for the molecular basis of cross-reactive idiotypes of TcR recognized by mAb." @default.
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• W2079717800 date "1991-02-01" @default.
• W2079717800 modified "2023-09-27" @default.
• W2079717800 title "Conserved V(D)J junctional sequence of cross-reactive cytotoxic T cell receptor idiotype and the effect of a single amino acid substitution" @default.
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• W2079717800 doi "https://doi.org/10.1002/eji.1830210234" @default.
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