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- W2079722265 abstract "Plasma dopamine-beta-hydroxylase (DBH) levels were measured every 30 or 60 minutes over 24 hours in normal subjects and in unipolar and bipolar depressed patients. A circadian rhythm characterized by the occurrence in the mid afternoon hours of a single peak of magnitude between 13 % and 39 % of the mean level was detected in all normal subjects. In depressed patients, significant episodic variations were frequent and the mid afternoon elevation no longer appeared as the sole major event in the 24-hour variation. To quantify these alterations, two indices, to be computed from the data, have been introduced. The Difference between the Coefficients of Variation (DCV) of the first half (8 A.M. to 8 P.M.) and the second half (8 P.M. to 8 A.M.) of the pattern characterizes the relative importance of the mid afternoon elevation whereas the Percentage of Low Frequencies (PLF) is a measure of the Variability of the pattern about its mean level. Deviations from normal were generally more important in bipolar than in unipolar patients but they did not correlate with the severity of the mood alterations. The PLF index allowed a discrimination between groups of unipolars and bipolars. Alterations of the 24-hour DBH pattern, quantified by DCV and PLF indices, could provide an objective biological indicator of endogenous depression." @default.
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- W2079722265 title "24-hour dopamine-beta-hydroxylase pattern: A possible biological index of manic-depression" @default.
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- W2079722265 doi "https://doi.org/10.1016/0024-3205(78)90531-3" @default.
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