FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079723706> ?p ?o ?g. }

• W2079723706 abstract "Ribonucleotide reductase (RNR), the enzyme responsible for the formation of deoxyribonucleotides from ribonucleotides, is found in all domains of life and many viral genomes. RNRs are also amongst the most abundant genes identified in environmental metagenomes. This study focused on understanding the distribution, diversity, and evolution of RNRs in phages (viruses that infect bacteria). Hidden Markov Model profiles were used to analyze the proteins encoded by 685 completely sequenced double-stranded DNA phages and 22 environmental viral metagenomes to identify RNR homologs in cultured phages and uncultured viral communities, respectively.RNRs were identified in 128 phage genomes, nearly tripling the number of phages known to encode RNRs. Class I RNR was the most common RNR class observed in phages (70%), followed by class II (29%) and class III (28%). Twenty-eight percent of the phages contained genes belonging to multiple RNR classes. RNR class distribution varied according to phage type, isolation environment, and the host's ability to utilize oxygen. The majority of the phages containing RNRs are Myoviridae (65%), followed by Siphoviridae (30%) and Podoviridae (3%). The phylogeny and genomic organization of phage and host RNRs reveal several distinct evolutionary scenarios involving horizontal gene transfer, co-evolution, and differential selection pressure. Several putative split RNR genes interrupted by self-splicing introns or inteins were identified, providing further evidence for the role of frequent genetic exchange. Finally, viral metagenomic data indicate that RNRs are prevalent and highly dynamic in uncultured viral communities, necessitating future research to determine the environmental conditions under which RNRs provide a selective advantage.This comprehensive study describes the distribution, diversity, and evolution of RNRs in phage genomes and environmental viral metagenomes. The distinct distributions of specific RNR classes amongst phages, combined with the various evolutionary scenarios predicted from RNR phylogenies suggest multiple inheritance sources and different selective forces for RNRs in phages. This study significantly improves our understanding of phage RNRs, providing insight into the diversity and evolution of this important auxiliary metabolic gene as well as the evolution of phages in response to their bacterial hosts and environments." @default.
• W2079723706 created "2016-06-24" @default.
• W2079723706 creator A5029764074 @default.
• W2079723706 creator A5036802114 @default.
• W2079723706 creator A5040229354 @default.
• W2079723706 creator A5047734861 @default.
• W2079723706 creator A5089189215 @default.
• W2079723706 date "2013-02-07" @default.
• W2079723706 modified "2023-10-13" @default.
• W2079723706 title "A bioinformatic analysis of ribonucleotide reductase genes in phage genomes and metagenomes" @default.
• W2079723706 cites W1498596118 @default.
• W2079723706 cites W1505193925 @default.
• W2079723706 cites W1514768507 @default.
• W2079723706 cites W1535652773 @default.
• W2079723706 cites W1563631267 @default.
• W2079723706 cites W1594338269 @default.
• W2079723706 cites W1605431685 @default.
• W2079723706 cites W1689364519 @default.
• W2079723706 cites W1695077289 @default.
• W2079723706 cites W1743164322 @default.
• W2079723706 cites W1858154647 @default.
• W2079723706 cites W1881332855 @default.
• W2079723706 cites W1963957860 @default.
• W2079723706 cites W1964783419 @default.
• W2079723706 cites W1971640379 @default.
• W2079723706 cites W1976313814 @default.
• W2079723706 cites W1976608804 @default.
• W2079723706 cites W1979420181 @default.
• W2079723706 cites W1981015633 @default.
• W2079723706 cites W1986945315 @default.
• W2079723706 cites W1991029445 @default.
• W2079723706 cites W1994421736 @default.
• W2079723706 cites W1995614275 @default.
• W2079723706 cites W2001573278 @default.
• W2079723706 cites W2002360525 @default.
• W2079723706 cites W2003162236 @default.
• W2079723706 cites W2004115765 @default.
• W2079723706 cites W2006309936 @default.
• W2079723706 cites W2006465310 @default.
• W2079723706 cites W2007761614 @default.
• W2079723706 cites W2008165954 @default.
• W2079723706 cites W2010817437 @default.
• W2079723706 cites W2012289098 @default.
• W2079723706 cites W2012482159 @default.
• W2079723706 cites W2016116455 @default.
• W2079723706 cites W2017876889 @default.
• W2079723706 cites W2019977292 @default.
• W2079723706 cites W2021958338 @default.
• W2079723706 cites W2022407459 @default.
• W2079723706 cites W2027638639 @default.
• W2079723706 cites W2031311643 @default.
• W2079723706 cites W2031441099 @default.
• W2079723706 cites W2037993016 @default.
• W2079723706 cites W2039040433 @default.
• W2079723706 cites W2041867733 @default.
• W2079723706 cites W2041926808 @default.
• W2079723706 cites W2046180712 @default.
• W2079723706 cites W2048091446 @default.
• W2079723706 cites W2050252362 @default.
• W2079723706 cites W2051643121 @default.
• W2079723706 cites W2054431621 @default.
• W2079723706 cites W2055579692 @default.
• W2079723706 cites W2056242137 @default.
• W2079723706 cites W2061680337 @default.
• W2079723706 cites W2062938532 @default.
• W2079723706 cites W2069689025 @default.
• W2079723706 cites W2073353609 @default.
• W2079723706 cites W2075147968 @default.
• W2079723706 cites W2076184415 @default.
• W2079723706 cites W2079706758 @default.
• W2079723706 cites W2080552505 @default.
• W2079723706 cites W2080651354 @default.
• W2079723706 cites W2081938884 @default.
• W2079723706 cites W2083521478 @default.
• W2079723706 cites W2084863783 @default.
• W2079723706 cites W2087024519 @default.
• W2079723706 cites W2093570935 @default.
• W2079723706 cites W2098132478 @default.
• W2079723706 cites W2103546861 @default.
• W2079723706 cites W2109456246 @default.
• W2079723706 cites W2109740998 @default.
• W2079723706 cites W2113078128 @default.
• W2079723706 cites W2114548104 @default.
• W2079723706 cites W2114868025 @default.
• W2079723706 cites W2119520197 @default.
• W2079723706 cites W2120010846 @default.
• W2079723706 cites W2120035402 @default.
• W2079723706 cites W2122473615 @default.
• W2079723706 cites W2122661959 @default.
• W2079723706 cites W2126291032 @default.
• W2079723706 cites W2127350454 @default.
• W2079723706 cites W2127730569 @default.
• W2079723706 cites W2132632499 @default.
• W2079723706 cites W2133723400 @default.
• W2079723706 cites W2135593313 @default.
• W2079723706 cites W2135621733 @default.
• W2079723706 cites W2141193948 @default.
• W2079723706 cites W2144184757 @default.
• W2079723706 cites W2144654387 @default.
• W2079723706 cites W2145698457 @default.

• next