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• W2079723981 abstract "<i>Background:</i> Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are known for their chemotactic and proinflammatory effects on monocytes/macrophages which have a cysteinyl leukotriene 1 (CysLT₁) receptor. <i>Methods:</i> We examined MIP-1α and MIP-1β production stimulated by CysLTs (LTC₄, LTD₄, and LTE₄) in THP-1 cells, a human monocytic leukemia cell line, and peripheral blood mononuclear cells (PBMCs). Moreover, we examined the inhibitory effect of pranlukast, a CysLT₁ receptor antagonist, and inhibitors of three major mitogen-activated protein kinases (MAPK) on the induction of MIP-1α and MIP-1β production by CysLTs. <i>Results:</i> ELISA demonstrated that CysLTs induced MIP-1α and MIP-1β production in THP-1 cells and PBMCs. PCR demonstrated that LTD₄ increased MIP-1α and MIP-1β mRNA expressions in THP-1 cells. Pranlukast blocked MIP-1α and MIP-1β production promoted by LTD₄ in THP-1 cells and PBMCs. Moreover, an inhibitor of extracellular signal-regulated kinase (ERK) attenuated the induction of MIP-1α and MIP-1β production by LTD₄ in THP-1 cells whereas the inhibitors of c-Jun NH2-terminal kinase or p38 MAPK did not. <i>Conclusion:</i> CysLTs induce MIP-1α and MIP-1β production mediated by ERK via binding to the CysLT₁ receptor in human monocytes/macrophages." @default.
• W2079723981 created "2016-06-24" @default.
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• W2079723981 date "2008-09-19" @default.
• W2079723981 modified "2023-10-17" @default.
• W2079723981 title "Cysteinyl Leukotrienes Induce Macrophage Inflammatory Protein-1 in Human Monocytes/Macrophages" @default.
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• W2079723981 doi "https://doi.org/10.1159/000155745" @default.
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