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- W2079724379 abstract "BARKER1 and Speert,2 in 1938, showed that sulfanilamide given to mothers before or during labor passed readily across the human placenta and could be demonstrated in umbilical-vein blood at the time of delivery. Subsequent studies by Speert3 , 4 indicated that sulfathiazole and sulfadiazine also traversed the placenta. He found that when these drugs were given orally during labor, they might be irregularly absorbed from the gastrointestinal tract, and therefore suggested their use intravenously3; when sodium sulfadiazine was so administered to mothers an equilibrium was established in about three hours between maternal and fetal blood. He suggested such treatment of the . . ." @default.
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- W2079724379 date "1957-12-12" @default.
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- W2079724379 title "Placental Transfer of Sulfamethoxypyridazine" @default.
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- W2079724379 doi "https://doi.org/10.1056/nejm195712122572407" @default.
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