Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079724650> ?p ?o ?g. }
- W2079724650 endingPage "1810" @default.
- W2079724650 startingPage "1800" @default.
- W2079724650 abstract "Progress in the biology of myo-inositol hexakisphosphate (InsP6) has been delayed by the lack of a quantitative description of its multiple interactions with divalent cations. Our recent initial description of these [J. Torres, S. Dominguez, M.F. Cerda, G. Obal, A. Mederos, R.F. Irvine, A. Diaz, C. Kremer, J. Inorg. Biochem. 99 (2005) 828–840] predicted that under cytosolic/nuclear conditions, protein-free soluble InsP6 occurs as Mg5(H2L), a neutral complex that exists thanks to a significant, but undefined, window of solubility displayed by solid Mg5(H2L) · 22H2O (L is fully deprotonated InsP6). Here we complete the description of the InsP6–Mg2+–Ca2+ system, defining the solubilities of the Mg2+ and Ca2+ (Ca5(H2L) · 16H2O) solids in terms of Ks0 = [M2+]5[H2L10−], with pKs0 = 32.93 for M = Mg and pKs0 = 39.3 for M = Ca. The concentration of soluble Mg5(H2L) at 37 °C and I = 0.15 M NaClO4 is limited to 49 μM, yet InsP6 in mammalian cells may reach 100 μM. Any cytosolic/nuclear InsP6 in excess of 49 μM must be protein- or membrane-bound, or as solid Mg5(H2L) · 22H2O, and any extracellular InsP6 (e.g. in plasma) is surely protein-bound." @default.
- W2079724650 created "2016-06-24" @default.
- W2079724650 creator A5026272209 @default.
- W2079724650 creator A5030195858 @default.
- W2079724650 creator A5039660815 @default.
- W2079724650 creator A5047402231 @default.
- W2079724650 creator A5048441053 @default.
- W2079724650 creator A5056553379 @default.
- W2079724650 creator A5073601826 @default.
- W2079724650 date "2006-11-01" @default.
- W2079724650 modified "2023-10-18" @default.
- W2079724650 title "The behaviour of myo-inositol hexakisphosphate in the presence of magnesium(II) and calcium(II): Protein-free soluble InsP6 is limited to 49 μM under cytosolic/nuclear conditions" @default.
- W2079724650 cites W140093196 @default.
- W2079724650 cites W1554027724 @default.
- W2079724650 cites W1599277155 @default.
- W2079724650 cites W1665506700 @default.
- W2079724650 cites W1738721709 @default.
- W2079724650 cites W1856515523 @default.
- W2079724650 cites W1927629618 @default.
- W2079724650 cites W1949684022 @default.
- W2079724650 cites W1966677529 @default.
- W2079724650 cites W1967698617 @default.
- W2079724650 cites W1968686367 @default.
- W2079724650 cites W1969732883 @default.
- W2079724650 cites W1972704395 @default.
- W2079724650 cites W1983536335 @default.
- W2079724650 cites W1984555609 @default.
- W2079724650 cites W1988158937 @default.
- W2079724650 cites W1989784515 @default.
- W2079724650 cites W1993950383 @default.
- W2079724650 cites W2005563141 @default.
- W2079724650 cites W2008335738 @default.
- W2079724650 cites W2011485328 @default.
- W2079724650 cites W2012349421 @default.
- W2079724650 cites W2012943907 @default.
- W2079724650 cites W2017901309 @default.
- W2079724650 cites W2020984242 @default.
- W2079724650 cites W2022648781 @default.
- W2079724650 cites W2023414036 @default.
- W2079724650 cites W2028494201 @default.
- W2079724650 cites W2034621379 @default.
- W2079724650 cites W2044424878 @default.
- W2079724650 cites W2051148199 @default.
- W2079724650 cites W2051741041 @default.
- W2079724650 cites W2052250113 @default.
- W2079724650 cites W2054296549 @default.
- W2079724650 cites W2057056988 @default.
- W2079724650 cites W2059141024 @default.
- W2079724650 cites W2059948216 @default.
- W2079724650 cites W2060965329 @default.
- W2079724650 cites W2061628381 @default.
- W2079724650 cites W2068762378 @default.
- W2079724650 cites W2069318538 @default.
- W2079724650 cites W2076366871 @default.
- W2079724650 cites W2080419891 @default.
- W2079724650 cites W2086192954 @default.
- W2079724650 cites W2086954797 @default.
- W2079724650 cites W2087107956 @default.
- W2079724650 cites W2094200474 @default.
- W2079724650 cites W2094351226 @default.
- W2079724650 cites W2095011792 @default.
- W2079724650 cites W2104433712 @default.
- W2079724650 cites W2116943566 @default.
- W2079724650 cites W2127067216 @default.
- W2079724650 cites W2133506204 @default.
- W2079724650 cites W2139694983 @default.
- W2079724650 cites W2146563540 @default.
- W2079724650 cites W2146718650 @default.
- W2079724650 cites W2150225976 @default.
- W2079724650 cites W2168987575 @default.
- W2079724650 cites W2171219272 @default.
- W2079724650 cites W4241765244 @default.
- W2079724650 cites W4252160256 @default.
- W2079724650 doi "https://doi.org/10.1016/j.jinorgbio.2006.06.016" @default.
- W2079724650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1874250" @default.
- W2079724650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16920196" @default.
- W2079724650 hasPublicationYear "2006" @default.
- W2079724650 type Work @default.
- W2079724650 sameAs 2079724650 @default.
- W2079724650 citedByCount "67" @default.
- W2079724650 countsByYear W20797246502012 @default.
- W2079724650 countsByYear W20797246502013 @default.
- W2079724650 countsByYear W20797246502014 @default.
- W2079724650 countsByYear W20797246502015 @default.
- W2079724650 countsByYear W20797246502016 @default.
- W2079724650 countsByYear W20797246502017 @default.
- W2079724650 countsByYear W20797246502018 @default.
- W2079724650 countsByYear W20797246502019 @default.
- W2079724650 countsByYear W20797246502020 @default.
- W2079724650 countsByYear W20797246502021 @default.
- W2079724650 countsByYear W20797246502022 @default.
- W2079724650 countsByYear W20797246502023 @default.
- W2079724650 crossrefType "journal-article" @default.
- W2079724650 hasAuthorship W2079724650A5026272209 @default.
- W2079724650 hasAuthorship W2079724650A5030195858 @default.
- W2079724650 hasAuthorship W2079724650A5039660815 @default.
- W2079724650 hasAuthorship W2079724650A5047402231 @default.
- W2079724650 hasAuthorship W2079724650A5048441053 @default.