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- W2079724669 endingPage "721" @default.
- W2079724669 startingPage "709" @default.
- W2079724669 abstract "In this Review, the authors provide a comprehensive overview of the role of macrophage dynamics in determining the initiation, progression and regression of atherosclerotic inflammation. Understanding the factors that determine the inflammatory state of the plaque may help to identify potential therapeutic targets for plaque regression. Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall. Through the analysis of the progression and regression of atherosclerosis in animal models, there is a growing understanding that the balance of macrophages in the plaque is dynamic and that both macrophage numbers and the inflammatory phenotype influence plaque fate. In this Review, we summarize recently identified pro- and anti-inflammatory pathways that link lipid and inflammation biology with the retention of macrophages in plaques, as well as factors that have the potential to promote their egress from these sites." @default.
- W2079724669 created "2016-06-24" @default.
- W2079724669 creator A5003275100 @default.
- W2079724669 creator A5035258831 @default.
- W2079724669 creator A5088448170 @default.
- W2079724669 date "2013-09-02" @default.
- W2079724669 modified "2023-10-14" @default.
- W2079724669 title "Macrophages in atherosclerosis: a dynamic balance" @default.
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