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• W2079724894 endingPage "5396" @default.
• W2079724894 startingPage "5388" @default.
• W2079724894 abstract "In addition to regulating estrogen receptor-dependent gene expression, 17β-estradiol (E2) can directly influence intracellular signaling. In primary cultured cerebellar neurons, E2 was previously shown to regulate growth and oncotic cell death via rapid stimulation of ERK1/2 signaling. Here we show that ERK1/2 signaling in the cerebellum of neonatal and mature rats was rapidly responsive to E2 and during development to the environmental estrogen bisphenol A (BPA). In vivo dose-response analysis for each estrogenic compound was performed by brief (6-min) intracerebellar injection, followed by rapid fixation and phosphorylation-state-specific immunohistochemistry to quantitatively characterize changes in activated ERK1/2 (pERK) immunopositive cell numbers. Beginning on postnatal d 8, E2 significantly influenced the number of pERK-positive cells in a cell-specific manner that was dependent on concentration and age but not sex. In cerebellar granule cells on postnatal d 10, E2 or BPA increased pERK-positive cell numbers at low doses (10−12 to 10−10m) and at higher (10−7 to 10−6m) concentrations. Intermediate concentrations of either estrogenic compound did not modify basal ERK signaling. Rapid E2-induced increases in pERK immunoreactivity were specific to the ERK1/2 pathway as demonstrated by coinjection of the mitogen-activated, ERK-activating kinase (MEK)1/2 inhibitor U0126. Coadministration of BPA (10−12 to 10−10m) with 10−10m E2 dose-dependently inhibited rapid E2-induced ERK1/2 activation in developing cerebellar neurons. The ability of BPA to act as a highly potent E2 mimetic and to also disrupt the rapid actions of E2 at very low concentrations during cerebellar development highlights the potential low-dose impact of xenoestrogens on the developing brain." @default.
• W2079724894 created "2016-06-24" @default.
• W2079724894 creator A5020032394 @default.
• W2079724894 creator A5024592074 @default.
• W2079724894 creator A5079437343 @default.
• W2079724894 creator A5086677869 @default.
• W2079724894 date "2005-12-01" @default.
• W2079724894 modified "2023-09-26" @default.
• W2079724894 title "Ontogeny of Rapid Estrogen-Mediated Extracellular Signal-Regulated Kinase Signaling in the Rat Cerebellar Cortex: Potent Nongenomic Agonist and Endocrine Disrupting Activity of the Xenoestrogen Bisphenol A" @default.
• W2079724894 cites W1727806076 @default.
• W2079724894 cites W1809411463 @default.
• W2079724894 cites W1825306297 @default.
• W2079724894 cites W1830240816 @default.
• W2079724894 cites W1920826459 @default.
• W2079724894 cites W1963092557 @default.
• W2079724894 cites W1966773429 @default.
• W2079724894 cites W1968352627 @default.
• W2079724894 cites W1968614586 @default.
• W2079724894 cites W1973320610 @default.
• W2079724894 cites W1975912787 @default.
• W2079724894 cites W1982546336 @default.
• W2079724894 cites W1983088403 @default.
• W2079724894 cites W1986955479 @default.
• W2079724894 cites W1987321973 @default.
• W2079724894 cites W1988945933 @default.
• W2079724894 cites W1990979633 @default.
• W2079724894 cites W2008986529 @default.
• W2079724894 cites W2010667807 @default.
• W2079724894 cites W2010828018 @default.
• W2079724894 cites W2011053271 @default.
• W2079724894 cites W2016056600 @default.
• W2079724894 cites W2017264053 @default.
• W2079724894 cites W2018090541 @default.
• W2079724894 cites W2018407641 @default.
• W2079724894 cites W2020038984 @default.
• W2079724894 cites W2029193046 @default.
• W2079724894 cites W2029367797 @default.
• W2079724894 cites W2032057219 @default.
• W2079724894 cites W2032479830 @default.
• W2079724894 cites W2033936075 @default.
• W2079724894 cites W2034509805 @default.
• W2079724894 cites W2036238275 @default.
• W2079724894 cites W2039287048 @default.
• W2079724894 cites W2044598637 @default.
• W2079724894 cites W2045559518 @default.
• W2079724894 cites W2049970571 @default.
• W2079724894 cites W2052927712 @default.
• W2079724894 cites W2053642343 @default.
• W2079724894 cites W2056495400 @default.
• W2079724894 cites W2058756954 @default.
• W2079724894 cites W2067380913 @default.
• W2079724894 cites W2067642579 @default.
• W2079724894 cites W2068687971 @default.
• W2079724894 cites W2072239664 @default.
• W2079724894 cites W2072531719 @default.
• W2079724894 cites W2073883348 @default.
• W2079724894 cites W2076960629 @default.
• W2079724894 cites W2077046953 @default.
• W2079724894 cites W2078513326 @default.
• W2079724894 cites W2080133788 @default.
• W2079724894 cites W2082417638 @default.
• W2079724894 cites W2088354566 @default.
• W2079724894 cites W2090428300 @default.
• W2079724894 cites W2090991839 @default.
• W2079724894 cites W2104594573 @default.
• W2079724894 cites W2109879710 @default.
• W2079724894 cites W2120809075 @default.
• W2079724894 cites W2127673211 @default.
• W2079724894 cites W2129551080 @default.
• W2079724894 cites W2134085082 @default.
• W2079724894 cites W2134506701 @default.
• W2079724894 cites W2143006014 @default.
• W2079724894 cites W2145865543 @default.
• W2079724894 cites W2150771326 @default.
• W2079724894 cites W2152390280 @default.
• W2079724894 cites W2152427753 @default.
• W2079724894 cites W2154808997 @default.
• W2079724894 cites W2158864829 @default.
• W2079724894 cites W2168895138 @default.
• W2079724894 cites W2169294911 @default.
• W2079724894 cites W2327758174 @default.
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• W2079724894 doi "https://doi.org/10.1210/en.2005-0565" @default.
• W2079724894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16123166" @default.
• W2079724894 hasPublicationYear "2005" @default.
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