FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079725792> ?p ?o ?g. }

• W2079725792 endingPage "56" @default.
• W2079725792 startingPage "50" @default.
• W2079725792 abstract "We recently demonstrated that Polζ and Rev1 contribute to alleviate the lethal effects of Me-lex, which selectively generates 3-methyladenine, by error prone lesion bypass. In order to determine the role of Polη in the biological fate of Me-lex induced lesions, the RAD30 (Polη) gene was deleted in the yIG397 parental strain and in its rev3 (Polζ) derivative, and the strains transformed with plasmid DNA damaged in vitro by Me-lex. While deletion of RAD30 increased the toxicity of Me-lex, the impact on mutagenicity varied depending on the concentration of Me-lex induced DNA damage and the overall TLS capacity of the cells. For the first time the Me-lex induced mutation spectrum in rad30 strain was determined and compared with the spectrum previously determined in WT strain. Overall, the two mutation spectra were not significantly different. The effect on mutation frequency and the features of the Me-lex induced mutation spectra were suggestive of error prone (significant decrease of mutation frequency and significant decrease of AT > TA at a mutation hotspot in rad30 vs RAD30) but also error free (significant increase of AT > GC in rad30 vs RAD30) Polη dependent bypass of lesions. In summary, our previous results with Polζ and Rev1 mutants, the present results with Polη, and the known physical and functional interactions among TLS proteins, lead us to propose that the bypass of Me-lex induced lesions is a multi-DNA polymerases process that is mostly effective when all three yeast TLS polymerases are present." @default.
• W2079725792 created "2016-06-24" @default.
• W2079725792 creator A5011689251 @default.
• W2079725792 creator A5017062431 @default.
• W2079725792 creator A5020048624 @default.
• W2079725792 creator A5028711202 @default.
• W2079725792 creator A5039488879 @default.
• W2079725792 creator A5044744188 @default.
• W2079725792 creator A5057301830 @default.
• W2079725792 creator A5072259206 @default.
• W2079725792 creator A5087093113 @default.
• W2079725792 date "2010-01-01" @default.
• W2079725792 modified "2023-10-16" @default.
• W2079725792 title "Mutagenicity of N3-methyladenine: A multi-translesion polymerase affair" @default.
• W2079725792 cites W1509952187 @default.
• W2079725792 cites W1537970379 @default.
• W2079725792 cites W1538136289 @default.
• W2079725792 cites W1791564905 @default.
• W2079725792 cites W1994386041 @default.
• W2079725792 cites W1995038234 @default.
• W2079725792 cites W1998097191 @default.
• W2079725792 cites W2016184790 @default.
• W2079725792 cites W2025841293 @default.
• W2079725792 cites W2027772938 @default.
• W2079725792 cites W2046615942 @default.
• W2079725792 cites W2052965880 @default.
• W2079725792 cites W2057701529 @default.
• W2079725792 cites W2065626377 @default.
• W2079725792 cites W2070035980 @default.
• W2079725792 cites W2081059444 @default.
• W2079725792 cites W2089215158 @default.
• W2079725792 cites W2095809194 @default.
• W2079725792 cites W2098002585 @default.
• W2079725792 cites W2099367992 @default.
• W2079725792 cites W2100128333 @default.
• W2079725792 cites W2102091313 @default.
• W2079725792 cites W2102110656 @default.
• W2079725792 cites W2104647576 @default.
• W2079725792 cites W2112632636 @default.
• W2079725792 cites W2121671527 @default.
• W2079725792 cites W2124901566 @default.
• W2079725792 cites W2126264793 @default.
• W2079725792 cites W2126628078 @default.
• W2079725792 cites W2127838106 @default.
• W2079725792 cites W2139168208 @default.
• W2079725792 cites W2143064529 @default.
• W2079725792 cites W2148252052 @default.
• W2079725792 cites W2150763803 @default.
• W2079725792 cites W2153845158 @default.
• W2079725792 cites W2154518311 @default.
• W2079725792 cites W2165494710 @default.
• W2079725792 cites W4234412137 @default.
• W2079725792 doi "https://doi.org/10.1016/j.mrfmmm.2009.10.007" @default.
• W2079725792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2794908" @default.
• W2079725792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19874831" @default.
• W2079725792 hasPublicationYear "2010" @default.
• W2079725792 type Work @default.
• W2079725792 sameAs 2079725792 @default.
• W2079725792 citedByCount "22" @default.
• W2079725792 countsByYear W20797257922012 @default.
• W2079725792 countsByYear W20797257922013 @default.
• W2079725792 countsByYear W20797257922014 @default.
• W2079725792 countsByYear W20797257922015 @default.
• W2079725792 countsByYear W20797257922016 @default.
• W2079725792 countsByYear W20797257922018 @default.
• W2079725792 countsByYear W20797257922020 @default.
• W2079725792 countsByYear W20797257922021 @default.
• W2079725792 countsByYear W20797257922022 @default.
• W2079725792 crossrefType "journal-article" @default.
• W2079725792 hasAuthorship W2079725792A5011689251 @default.
• W2079725792 hasAuthorship W2079725792A5017062431 @default.
• W2079725792 hasAuthorship W2079725792A5020048624 @default.
• W2079725792 hasAuthorship W2079725792A5028711202 @default.
• W2079725792 hasAuthorship W2079725792A5039488879 @default.
• W2079725792 hasAuthorship W2079725792A5044744188 @default.
• W2079725792 hasAuthorship W2079725792A5057301830 @default.
• W2079725792 hasAuthorship W2079725792A5072259206 @default.
• W2079725792 hasAuthorship W2079725792A5087093113 @default.
• W2079725792 hasBestOaLocation W20797257922 @default.
• W2079725792 hasConcept C104317684 @default.
• W2079725792 hasConcept C134935766 @default.
• W2079725792 hasConcept C143065580 @default.
• W2079725792 hasConcept C143425029 @default.
• W2079725792 hasConcept C153911025 @default.
• W2079725792 hasConcept C22744801 @default.
• W2079725792 hasConcept C2756471 @default.
• W2079725792 hasConcept C501734568 @default.
• W2079725792 hasConcept C54355233 @default.
• W2079725792 hasConcept C552990157 @default.
• W2079725792 hasConcept C82381507 @default.
• W2079725792 hasConcept C86803240 @default.
• W2079725792 hasConceptScore W2079725792C104317684 @default.
• W2079725792 hasConceptScore W2079725792C134935766 @default.
• W2079725792 hasConceptScore W2079725792C143065580 @default.
• W2079725792 hasConceptScore W2079725792C143425029 @default.
• W2079725792 hasConceptScore W2079725792C153911025 @default.
• W2079725792 hasConceptScore W2079725792C22744801 @default.
• W2079725792 hasConceptScore W2079725792C2756471 @default.

• next