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• W2079729042 endingPage "5788" @default.
• W2079729042 startingPage "5779" @default.
• W2079729042 abstract "Under hypoxia, HIF-1alpha binds to aryl hydrocarbon receptor nuclear translocator (ARNT, also called HIF-1beta) to activate expression of genes important for cell survival. Alternatively, HIF-1alpha can bind to the tumor suppressor p53 and promote p53-dependent apoptosis. Here we show that the opposite functions of HIF-1alpha are distinguished by its phosphorylation status. Two distinguishable forms of HIF-1alpha, phosphorylated and dephosphorylated, were induced during hypoxia-induced apoptosis. The phosphorylated HIF-1alpha was the major form that bound to ARNT. Ectopically expressed ARNT was consistently able to enhance HIF-1alpha phosphorylation in a binding-dependent manner. In contrast, the dephosphorylated HIF-1alpha was the major form that bound to p53. Depletion of the dephosphorylated HIF-1alpha, by using the Hsp90 inhibitor geldanamycin A that had little effect on the phosphorylated HIF-1alpha expression, suppressed p53 induction and subsequent apoptosis. Depletion of dephosphorylated HIF-1alpha also prevented hypoxia-induced nuclear accumulation of HDM2, a negative regulator of p53. Our results indicate that the functions of HIF-1alpha varied with its phosphorylation status and that dephosphorylated HIF-1alpha mediated apoptosis by binding to and stabilizing p53." @default.
• W2079729042 created "2016-06-24" @default.
• W2079729042 creator A5006459642 @default.
• W2079729042 creator A5021580294 @default.
• W2079729042 creator A5033231895 @default.
• W2079729042 date "2001-09-13" @default.
• W2079729042 modified "2023-10-09" @default.
• W2079729042 title "Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia" @default.
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• W2079729042 doi "https://doi.org/10.1038/sj.onc.1204742" @default.
• W2079729042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11593383" @default.
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