Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079730685> ?p ?o ?g. }
- W2079730685 endingPage "167" @default.
- W2079730685 startingPage "136" @default.
- W2079730685 abstract "Malaria, particularly that one caused by Plasmodium falciparum, remains a serious health problem in Africa, South America, and many parts of Asia where it afflicts about 500 million people and is responsible for the death of more than one million children each year. The main reasons for the persistence of malaria are the emergence of resistance to common antimalarial drugs, inadequate control of mosquito vectors, and the lack of effective vaccines. Therefore, the identification and characterization of new targets for antimalarial chemotherapy are of urgent priority. This review is focused on inhibitors of falcipain-2, a cysteine protease from P. falciparum, which represents one of the most promising targets for antimalarial drug design. Falcipain-2 is a key enzyme in the life cycle of P. falciparum since it degrades hemoglobin, at the early trophozoite stage, and cleaves ankyrin and protein 4.1, the cytoskeletal elements vital to the stability of red cell membrane, at the schizont stage. The main classes of falcipain-2 inhibitors are peptides or peptidomimetics bearing the most popular pharmacophores of cysteine protease inhibitors, such as vinyl sulfones, halomethyl ketones, and aldehydes. Furthermore, many other chemotypes have been identified as inhibitors of falcipain-2, such as isoquinolines, thiosemicarbazones, and chalcones. These inhibitors represent all classes, which, to the best of our knowledge, have been disclosed in journal articles to date. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 1, 136–167, 2010" @default.
- W2079730685 created "2016-06-24" @default.
- W2079730685 creator A5006121739 @default.
- W2079730685 creator A5010004061 @default.
- W2079730685 creator A5039535977 @default.
- W2079730685 creator A5063112917 @default.
- W2079730685 creator A5081280580 @default.
- W2079730685 date "2009-06-12" @default.
- W2079730685 modified "2023-10-18" @default.
- W2079730685 title "Falcipain-2 inhibitors" @default.
- W2079730685 cites W1493715460 @default.
- W2079730685 cites W1536233937 @default.
- W2079730685 cites W1561401282 @default.
- W2079730685 cites W1730185705 @default.
- W2079730685 cites W1964451754 @default.
- W2079730685 cites W1965630099 @default.
- W2079730685 cites W1965929016 @default.
- W2079730685 cites W1966406246 @default.
- W2079730685 cites W1972161284 @default.
- W2079730685 cites W1972181859 @default.
- W2079730685 cites W1973470114 @default.
- W2079730685 cites W1974261970 @default.
- W2079730685 cites W1974931121 @default.
- W2079730685 cites W1975675098 @default.
- W2079730685 cites W1976757612 @default.
- W2079730685 cites W1976957132 @default.
- W2079730685 cites W1977724107 @default.
- W2079730685 cites W1978067320 @default.
- W2079730685 cites W1978945821 @default.
- W2079730685 cites W1982809233 @default.
- W2079730685 cites W1983953751 @default.
- W2079730685 cites W1984075743 @default.
- W2079730685 cites W1987213888 @default.
- W2079730685 cites W1987575637 @default.
- W2079730685 cites W1989078243 @default.
- W2079730685 cites W1991206160 @default.
- W2079730685 cites W1995465588 @default.
- W2079730685 cites W2000626569 @default.
- W2079730685 cites W2000784002 @default.
- W2079730685 cites W2004285059 @default.
- W2079730685 cites W2006569606 @default.
- W2079730685 cites W2007416146 @default.
- W2079730685 cites W2008590973 @default.
- W2079730685 cites W2008744126 @default.
- W2079730685 cites W2009972285 @default.
- W2079730685 cites W2012931700 @default.
- W2079730685 cites W2014862126 @default.
- W2079730685 cites W2017256889 @default.
- W2079730685 cites W2019851585 @default.
- W2079730685 cites W2021967959 @default.
- W2079730685 cites W2023687237 @default.
- W2079730685 cites W2026167307 @default.
- W2079730685 cites W2029985793 @default.
- W2079730685 cites W2031796366 @default.
- W2079730685 cites W2032986124 @default.
- W2079730685 cites W2033702197 @default.
- W2079730685 cites W2034037368 @default.
- W2079730685 cites W2034213780 @default.
- W2079730685 cites W2040826364 @default.
- W2079730685 cites W2040856541 @default.
- W2079730685 cites W2041704786 @default.
- W2079730685 cites W2047474710 @default.
- W2079730685 cites W2047771637 @default.
- W2079730685 cites W2048834380 @default.
- W2079730685 cites W2051527241 @default.
- W2079730685 cites W2051905139 @default.
- W2079730685 cites W2055058477 @default.
- W2079730685 cites W2055813456 @default.
- W2079730685 cites W2057059334 @default.
- W2079730685 cites W2061822300 @default.
- W2079730685 cites W2063952343 @default.
- W2079730685 cites W2064855181 @default.
- W2079730685 cites W2068403499 @default.
- W2079730685 cites W2068603872 @default.
- W2079730685 cites W2069414025 @default.
- W2079730685 cites W2074601302 @default.
- W2079730685 cites W2074874530 @default.
- W2079730685 cites W2075682016 @default.
- W2079730685 cites W2075716788 @default.
- W2079730685 cites W2076050649 @default.
- W2079730685 cites W2077524973 @default.
- W2079730685 cites W2079864942 @default.
- W2079730685 cites W2081327421 @default.
- W2079730685 cites W2083436957 @default.
- W2079730685 cites W2083762132 @default.
- W2079730685 cites W2085114820 @default.
- W2079730685 cites W2085165831 @default.
- W2079730685 cites W2085887238 @default.
- W2079730685 cites W2088298861 @default.
- W2079730685 cites W2088671665 @default.
- W2079730685 cites W2089231191 @default.
- W2079730685 cites W2090066697 @default.
- W2079730685 cites W2091879499 @default.
- W2079730685 cites W2092370541 @default.
- W2079730685 cites W2097808534 @default.
- W2079730685 cites W2102117283 @default.
- W2079730685 cites W2102227937 @default.
- W2079730685 cites W2103215838 @default.