Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079730977> ?p ?o ?g. }
- W2079730977 endingPage "436" @default.
- W2079730977 startingPage "427" @default.
- W2079730977 abstract "The effects of maneb were investigated in C57BL/6 Nrf2 wildtype and knockout mice. Treated KO mice showed significant weight loss as compared to WT counterparts. ICPAAS analysis demonstrated a significant increase in manganese concentration in the tissues of treated KO mice as compared to WT. Biochemical analysis revealed significant decreases of antioxidants including glutathione, glutathione reductase and heme oxygenase-1. Levels of TBARS were significantly increased in hippocampal tissue in Nrf2 KO mice at the 30 and 60 mg doses. qPCR demonstrated that the only gene mediated by the Nrf2 transcription pathway that was significantly modulated by at least 1.5 fold was glutathione peroxidase 4. GPX4 was significantly upregulated in Nrf2 WT mice treated with 30 mg/kg maneb and significantly downregulated in Nrf2 KO mice treated with the same dose. Microscopy revealed neuronal pyknosis and eosinophilia of the cytoplasm in the hippocampi of both WT and KO animals treated with 60 mg/kg maneb." @default.
- W2079730977 created "2016-06-24" @default.
- W2079730977 creator A5008022734 @default.
- W2079730977 creator A5067644279 @default.
- W2079730977 date "2013-09-01" @default.
- W2079730977 modified "2023-10-05" @default.
- W2079730977 title "Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice" @default.
- W2079730977 cites W1480653959 @default.
- W2079730977 cites W1502445277 @default.
- W2079730977 cites W1625092822 @default.
- W2079730977 cites W1948225098 @default.
- W2079730977 cites W1971455143 @default.
- W2079730977 cites W1971732805 @default.
- W2079730977 cites W1972290450 @default.
- W2079730977 cites W1986070505 @default.
- W2079730977 cites W1989603202 @default.
- W2079730977 cites W2001019228 @default.
- W2079730977 cites W2001288684 @default.
- W2079730977 cites W2004798196 @default.
- W2079730977 cites W2007794772 @default.
- W2079730977 cites W2015243552 @default.
- W2079730977 cites W2028243150 @default.
- W2079730977 cites W2039011889 @default.
- W2079730977 cites W2039144787 @default.
- W2079730977 cites W2052122421 @default.
- W2079730977 cites W2053032861 @default.
- W2079730977 cites W2065397424 @default.
- W2079730977 cites W2065925554 @default.
- W2079730977 cites W2066639890 @default.
- W2079730977 cites W2069683377 @default.
- W2079730977 cites W2075943484 @default.
- W2079730977 cites W2078742462 @default.
- W2079730977 cites W2079892215 @default.
- W2079730977 cites W2086988603 @default.
- W2079730977 cites W2089097264 @default.
- W2079730977 cites W2094965528 @default.
- W2079730977 cites W2096261918 @default.
- W2079730977 cites W2101692904 @default.
- W2079730977 cites W2113451311 @default.
- W2079730977 cites W2118422955 @default.
- W2079730977 cites W2121355588 @default.
- W2079730977 cites W2136262030 @default.
- W2079730977 cites W2154575706 @default.
- W2079730977 cites W2155324869 @default.
- W2079730977 cites W2160099189 @default.
- W2079730977 cites W2162289848 @default.
- W2079730977 cites W4234756901 @default.
- W2079730977 doi "https://doi.org/10.1016/j.etap.2013.04.016" @default.
- W2079730977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23764462" @default.
- W2079730977 hasPublicationYear "2013" @default.
- W2079730977 type Work @default.
- W2079730977 sameAs 2079730977 @default.
- W2079730977 citedByCount "23" @default.
- W2079730977 countsByYear W20797309772014 @default.
- W2079730977 countsByYear W20797309772016 @default.
- W2079730977 countsByYear W20797309772017 @default.
- W2079730977 countsByYear W20797309772018 @default.
- W2079730977 countsByYear W20797309772019 @default.
- W2079730977 countsByYear W20797309772020 @default.
- W2079730977 countsByYear W20797309772021 @default.
- W2079730977 countsByYear W20797309772022 @default.
- W2079730977 countsByYear W20797309772023 @default.
- W2079730977 crossrefType "journal-article" @default.
- W2079730977 hasAuthorship W2079730977A5008022734 @default.
- W2079730977 hasAuthorship W2079730977A5067644279 @default.
- W2079730977 hasConcept C126322002 @default.
- W2079730977 hasConcept C134018914 @default.
- W2079730977 hasConcept C153911025 @default.
- W2079730977 hasConcept C165069038 @default.
- W2079730977 hasConcept C170493617 @default.
- W2079730977 hasConcept C181199279 @default.
- W2079730977 hasConcept C182704531 @default.
- W2079730977 hasConcept C185592680 @default.
- W2079730977 hasConcept C2776368712 @default.
- W2079730977 hasConcept C2777352226 @default.
- W2079730977 hasConcept C2778760513 @default.
- W2079730977 hasConcept C2779743564 @default.
- W2079730977 hasConcept C538909803 @default.
- W2079730977 hasConcept C55493867 @default.
- W2079730977 hasConcept C59822182 @default.
- W2079730977 hasConcept C71924100 @default.
- W2079730977 hasConcept C74600772 @default.
- W2079730977 hasConcept C86803240 @default.
- W2079730977 hasConceptScore W2079730977C126322002 @default.
- W2079730977 hasConceptScore W2079730977C134018914 @default.
- W2079730977 hasConceptScore W2079730977C153911025 @default.
- W2079730977 hasConceptScore W2079730977C165069038 @default.
- W2079730977 hasConceptScore W2079730977C170493617 @default.
- W2079730977 hasConceptScore W2079730977C181199279 @default.
- W2079730977 hasConceptScore W2079730977C182704531 @default.
- W2079730977 hasConceptScore W2079730977C185592680 @default.
- W2079730977 hasConceptScore W2079730977C2776368712 @default.
- W2079730977 hasConceptScore W2079730977C2777352226 @default.
- W2079730977 hasConceptScore W2079730977C2778760513 @default.
- W2079730977 hasConceptScore W2079730977C2779743564 @default.
- W2079730977 hasConceptScore W2079730977C538909803 @default.
- W2079730977 hasConceptScore W2079730977C55493867 @default.
- W2079730977 hasConceptScore W2079730977C59822182 @default.