FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079732247> ?p ?o ?g. }

• W2079732247 endingPage "49" @default.
• W2079732247 startingPage "40" @default.
• W2079732247 abstract "Age-dependent changes related to liver injury and regeneration were studied in rats aged 2, 12, and 30 months in a time period of 96 hr following a sublethal dose of thioacetamide (6.6 mmoles/kg body wt). Serum aspartate aminotransferase activity increased earlier in young rats, but the severity of injury was higher in those aged 12 months when compared to young and to old. Microsomal hepatocyte FAD monooxygenase activity was induced earlier in 2-month-old rats following intoxication and the increase was significantly lower both in the youngest and in the oldest groups when compared to adults. As a parameter of hepatocellular postnecrotic regeneration, DNA synthesis (2C → 4C) was evaluated. The population of hepatocytes in S phase peaked more sharply and earlier in young rat hepatocytes, and was 8 to 12 times higher than the initial in hepatocytes from 2- and 12-month-old rats, while the rise was only 3 times in the oldest group. At 96 hr of intoxication the restoration towards normal in all these parameters was complete in young, incomplete in adult, and slightly detected in the oldest. Serum proliferative activity, assayed on mouse NIH 3T3 fibroblast cultures, increased preceding the necrosis and this increase was higher in 2- and 12-month-old (171% and 224%, respectively), while in the oldest the increase was only 110%. This mitogenic activity decreased in all groups during necrosis, showing a second peak, nondetectable in rats aged 30 months, parallel to regeneration. Serum TNFα level was absent in untreated animals and increased markedly following intoxication, the highest values being recorded at 72 hr of intoxication in serum from rats aged 12 months (347 ± 30 pg/ml) and the lowest at 30 months (4.1 ± 0.3 pg/ml). The serum ability to induce nitric oxide synthase activity on peritoneal macrophagesex vivoshowed significant time- and age-dependent changes in nitric oxide release: a decrease throughout necrosis and an increase during regeneration. We conclude that the main age-related changes in the sequenced process of liver injury and regeneration are the delayed response in the development of cell killing and regeneration and the decreased regenerative ability, which significantly delays the restoration of liver function." @default.
• W2079732247 created "2016-06-24" @default.
• W2079732247 creator A5013231346 @default.
• W2079732247 creator A5014894641 @default.
• W2079732247 creator A5034846300 @default.
• W2079732247 creator A5047236785 @default.
• W2079732247 creator A5077764389 @default.
• W2079732247 date "1999-01-01" @default.
• W2079732247 modified "2023-10-02" @default.
• W2079732247 title "Age-Related Changes on Parameters of Experimentally-Induced Liver Injury and Regeneration" @default.
• W2079732247 cites W1508875062 @default.
• W2079732247 cites W1554913031 @default.
• W2079732247 cites W1563645938 @default.
• W2079732247 cites W1589578406 @default.
• W2079732247 cites W1607009526 @default.
• W2079732247 cites W1975333022 @default.
• W2079732247 cites W1977379434 @default.
• W2079732247 cites W1978018003 @default.
• W2079732247 cites W1986092783 @default.
• W2079732247 cites W1987860354 @default.
• W2079732247 cites W1990802251 @default.
• W2079732247 cites W2000101394 @default.
• W2079732247 cites W2002634680 @default.
• W2079732247 cites W2004343006 @default.
• W2079732247 cites W2013114215 @default.
• W2079732247 cites W2015044557 @default.
• W2079732247 cites W2018064659 @default.
• W2079732247 cites W2026261400 @default.
• W2079732247 cites W2046750945 @default.
• W2079732247 cites W2056636760 @default.
• W2079732247 cites W2059215353 @default.
• W2079732247 cites W2060989173 @default.
• W2079732247 cites W2070844062 @default.
• W2079732247 cites W2075645013 @default.
• W2079732247 cites W2079168469 @default.
• W2079732247 cites W2087423245 @default.
• W2079732247 cites W2090678963 @default.
• W2079732247 cites W2169162593 @default.
• W2079732247 cites W2175770380 @default.
• W2079732247 cites W2181148302 @default.
• W2079732247 cites W2198974858 @default.
• W2079732247 cites W3023167551 @default.
• W2079732247 cites W4293247451 @default.
• W2079732247 doi "https://doi.org/10.1006/taap.1998.8541" @default.
• W2079732247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9882590" @default.
• W2079732247 hasPublicationYear "1999" @default.
• W2079732247 type Work @default.
• W2079732247 sameAs 2079732247 @default.
• W2079732247 citedByCount "56" @default.
• W2079732247 countsByYear W20797322472012 @default.
• W2079732247 countsByYear W20797322472013 @default.
• W2079732247 countsByYear W20797322472014 @default.
• W2079732247 countsByYear W20797322472015 @default.
• W2079732247 countsByYear W20797322472017 @default.
• W2079732247 countsByYear W20797322472018 @default.
• W2079732247 countsByYear W20797322472019 @default.
• W2079732247 countsByYear W20797322472020 @default.
• W2079732247 countsByYear W20797322472021 @default.
• W2079732247 countsByYear W20797322472022 @default.
• W2079732247 crossrefType "journal-article" @default.
• W2079732247 hasAuthorship W2079732247A5013231346 @default.
• W2079732247 hasAuthorship W2079732247A5014894641 @default.
• W2079732247 hasAuthorship W2079732247A5034846300 @default.
• W2079732247 hasAuthorship W2079732247A5047236785 @default.
• W2079732247 hasAuthorship W2079732247A5077764389 @default.
• W2079732247 hasConcept C126322002 @default.
• W2079732247 hasConcept C134018914 @default.
• W2079732247 hasConcept C171056886 @default.
• W2079732247 hasConcept C185592680 @default.
• W2079732247 hasConcept C202751555 @default.
• W2079732247 hasConcept C2776200302 @default.
• W2079732247 hasConcept C2776637226 @default.
• W2079732247 hasConcept C2776795407 @default.
• W2079732247 hasConcept C2781057625 @default.
• W2079732247 hasConcept C2908647359 @default.
• W2079732247 hasConcept C503630168 @default.
• W2079732247 hasConcept C55493867 @default.
• W2079732247 hasConcept C71924100 @default.
• W2079732247 hasConcept C86803240 @default.
• W2079732247 hasConcept C95444343 @default.
• W2079732247 hasConcept C99454951 @default.
• W2079732247 hasConceptScore W2079732247C126322002 @default.
• W2079732247 hasConceptScore W2079732247C134018914 @default.
• W2079732247 hasConceptScore W2079732247C171056886 @default.
• W2079732247 hasConceptScore W2079732247C185592680 @default.
• W2079732247 hasConceptScore W2079732247C202751555 @default.
• W2079732247 hasConceptScore W2079732247C2776200302 @default.
• W2079732247 hasConceptScore W2079732247C2776637226 @default.
• W2079732247 hasConceptScore W2079732247C2776795407 @default.
• W2079732247 hasConceptScore W2079732247C2781057625 @default.
• W2079732247 hasConceptScore W2079732247C2908647359 @default.
• W2079732247 hasConceptScore W2079732247C503630168 @default.
• W2079732247 hasConceptScore W2079732247C55493867 @default.
• W2079732247 hasConceptScore W2079732247C71924100 @default.
• W2079732247 hasConceptScore W2079732247C86803240 @default.
• W2079732247 hasConceptScore W2079732247C95444343 @default.
• W2079732247 hasConceptScore W2079732247C99454951 @default.
• W2079732247 hasIssue "1" @default.

• next