FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079733392> ?p ?o ?g. }

• W2079733392 endingPage "365" @default.
• W2079733392 startingPage "360" @default.
• W2079733392 abstract "The activation of extracellular receptor kinase (ERK) is one of the checkpoints to assess the activation of the classical Ras/mitogen-activated protein kinase (MAPK) cascade. Therefore, we tested more than 100 selenium-containing compounds for their ability to activate the MAPK signal pathway. Among them, we found that three selenazoles, 5-chloroacetyl-2-piperidino-1,3-selenazole (CS1), 5-chloroacetyl-2-morpholino-1,3-selenazole (CS2), and 5-chloroacetyl-2-dimethylamino-1,3-selenazole (CS3), induced the phosphorylation of ERK. These compounds also enhanced the phosphorylation of Akt, a signal transducing protein kinase for cell survival; and this phosphorylation was followed by suppression of cell death, thus suggesting that they had anti-apoptotic effects. Moreover, CSs 1–3 induced neurite outgrowth and facilitated the expression of neurofilament-M of PC12 cells, demonstrating that they induced neuronal differentiation of these cells. On the other hand, the CS-induced phosphorylation of MAPK was enhanced by buthionine sulfoximine (BSO), an activator of protein tyrosine phosphatases (PTPs), but inhibited by N-acetyl-l-cysteine (NAC), an inhibitor of receptor tyrosine kinase. These results imply that activation of some receptor tyrosine kinase(s) is involved in the mechanism of action of CSs 1–3. The activation of MAPK by CSs 1–3 was suppressed by U0126, a MEK inhibitor, but not by K252a, an inhibitor of TrkA; AG1478, an antagonist of epidermal growth factor receptor (EGFR); or by pertussis toxin. These results demonstrate that the CS-induced phosphorylation of Akt and MAP kinase (receptor tyrosine kinase(s)-MEK1/2-ERK1/2) cascades was responsible for suppression of apoptosis and facilitation of neuronal differentiation of PC12 cells, respectively. Our results suggest that CSs 1–3 are promising candidates as neuroprotective and/or neurotrophic agents for the treatment of various neurodegenerative neurological disorders." @default.
• W2079733392 created "2016-06-24" @default.
• W2079733392 creator A5010287436 @default.
• W2079733392 creator A5011759251 @default.
• W2079733392 creator A5038648319 @default.
• W2079733392 creator A5057091545 @default.
• W2079733392 creator A5068962427 @default.
• W2079733392 date "2007-01-01" @default.
• W2079733392 modified "2023-10-12" @default.
• W2079733392 title "Selenazoles (selenium compounds) facilitate survival of cultured rat pheochromocytoma PC12 cells after serum-deprivation and stimulate their neuronal differentiation via activation of Akt and mitogen-activated protein kinase, respectively" @default.
• W2079733392 cites W1808434778 @default.
• W2079733392 cites W1967306889 @default.
• W2079733392 cites W1975047125 @default.
• W2079733392 cites W1994870126 @default.
• W2079733392 cites W2004198401 @default.
• W2079733392 cites W2007604354 @default.
• W2079733392 cites W2014781588 @default.
• W2079733392 cites W2019854747 @default.
• W2079733392 cites W2022658303 @default.
• W2079733392 cites W2040504184 @default.
• W2079733392 cites W2055179260 @default.
• W2079733392 cites W2069897341 @default.
• W2079733392 cites W2072732729 @default.
• W2079733392 cites W2078042930 @default.
• W2079733392 cites W2078815451 @default.
• W2079733392 cites W2090111748 @default.
• W2079733392 cites W2133405161 @default.
• W2079733392 cites W2154553662 @default.
• W2079733392 cites W2950255050 @default.
• W2079733392 doi "https://doi.org/10.1016/j.bbrc.2006.11.025" @default.
• W2079733392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17126295" @default.
• W2079733392 hasPublicationYear "2007" @default.
• W2079733392 type Work @default.
• W2079733392 sameAs 2079733392 @default.
• W2079733392 citedByCount "30" @default.
• W2079733392 countsByYear W20797333922012 @default.
• W2079733392 countsByYear W20797333922014 @default.
• W2079733392 countsByYear W20797333922015 @default.
• W2079733392 countsByYear W20797333922016 @default.
• W2079733392 countsByYear W20797333922017 @default.
• W2079733392 countsByYear W20797333922018 @default.
• W2079733392 countsByYear W20797333922019 @default.
• W2079733392 countsByYear W20797333922020 @default.
• W2079733392 countsByYear W20797333922021 @default.
• W2079733392 crossrefType "journal-article" @default.
• W2079733392 hasAuthorship W2079733392A5010287436 @default.
• W2079733392 hasAuthorship W2079733392A5011759251 @default.
• W2079733392 hasAuthorship W2079733392A5038648319 @default.
• W2079733392 hasAuthorship W2079733392A5057091545 @default.
• W2079733392 hasAuthorship W2079733392A5068962427 @default.
• W2079733392 hasConcept C101544691 @default.
• W2079733392 hasConcept C11960822 @default.
• W2079733392 hasConcept C137361374 @default.
• W2079733392 hasConcept C153911025 @default.
• W2079733392 hasConcept C170493617 @default.
• W2079733392 hasConcept C180361614 @default.
• W2079733392 hasConcept C185592680 @default.
• W2079733392 hasConcept C2775960820 @default.
• W2079733392 hasConcept C502942594 @default.
• W2079733392 hasConcept C55493867 @default.
• W2079733392 hasConcept C57074206 @default.
• W2079733392 hasConcept C75217442 @default.
• W2079733392 hasConcept C79186569 @default.
• W2079733392 hasConcept C85528070 @default.
• W2079733392 hasConcept C86803240 @default.
• W2079733392 hasConcept C90934575 @default.
• W2079733392 hasConcept C95444343 @default.
• W2079733392 hasConcept C97029542 @default.
• W2079733392 hasConceptScore W2079733392C101544691 @default.
• W2079733392 hasConceptScore W2079733392C11960822 @default.
• W2079733392 hasConceptScore W2079733392C137361374 @default.
• W2079733392 hasConceptScore W2079733392C153911025 @default.
• W2079733392 hasConceptScore W2079733392C170493617 @default.
• W2079733392 hasConceptScore W2079733392C180361614 @default.
• W2079733392 hasConceptScore W2079733392C185592680 @default.
• W2079733392 hasConceptScore W2079733392C2775960820 @default.
• W2079733392 hasConceptScore W2079733392C502942594 @default.
• W2079733392 hasConceptScore W2079733392C55493867 @default.
• W2079733392 hasConceptScore W2079733392C57074206 @default.
• W2079733392 hasConceptScore W2079733392C75217442 @default.
• W2079733392 hasConceptScore W2079733392C79186569 @default.
• W2079733392 hasConceptScore W2079733392C85528070 @default.
• W2079733392 hasConceptScore W2079733392C86803240 @default.
• W2079733392 hasConceptScore W2079733392C90934575 @default.
• W2079733392 hasConceptScore W2079733392C95444343 @default.
• W2079733392 hasConceptScore W2079733392C97029542 @default.
• W2079733392 hasIssue "2" @default.
• W2079733392 hasLocation W20797333921 @default.
• W2079733392 hasLocation W20797333922 @default.
• W2079733392 hasOpenAccess W2079733392 @default.
• W2079733392 hasPrimaryLocation W20797333921 @default.
• W2079733392 hasRelatedWork W1850687213 @default.
• W2079733392 hasRelatedWork W2005941786 @default.
• W2079733392 hasRelatedWork W2026467468 @default.
• W2079733392 hasRelatedWork W2041981800 @default.
• W2079733392 hasRelatedWork W2047744275 @default.
• W2079733392 hasRelatedWork W2057636788 @default.
• W2079733392 hasRelatedWork W2105024940 @default.

• next