FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079733906> ?p ?o ?g. }

• W2079733906 endingPage "853" @default.
• W2079733906 startingPage "847" @default.
• W2079733906 abstract "To evaluate the concept that long duration of action is an advantageous property of angiotensin-converting enzyme inhibitors in the treatment of severe heart failure, we randomly assigned 42 patients to therapy with either a short-acting inhibitor (captopril, 150 mg daily) or a long-acting inhibitor (enalapril, 40 mg daily) for one to three months while concomitant therapy with digoxin and diuretics was kept constant. The treatment groups had similar hemodynamic and clinical characteristics at base-line evaluation and similar initial responses to converting-enzyme inhibition. During long-term therapy, captopril and enalapril produced similar decreases in systemic blood pressure, but the hypotensive effects of enalapril were more prolonged and persistent than those of captopril. Consequently, although the patients in both groups improved hemodynamically and clinically during the study, serious symptomatic hypotension (syncope and near syncope) was seen primarily among those treated with enalapril. Sustained hypotension also probably accounted for the decline in creatinine clearance (P less than 0.05) and the notable retention of potassium (P less than 0.05) observed in the patients treated with enalapril but not in those treated with captopril. We conclude that when large, fixed doses of converting-enzyme inhibitors are used in the treatment of patients with severe chronic heart failure, long-acting agents may produce prolonged hypotensive effects that may compromise cerebral and renal function, and thus they may have disadvantages in such cases, as compared with short-acting agents." @default.
• W2079733906 created "2016-06-24" @default.
• W2079733906 creator A5022643632 @default.
• W2079733906 creator A5026223939 @default.
• W2079733906 creator A5028128654 @default.
• W2079733906 creator A5042766753 @default.
• W2079733906 date "1986-10-02" @default.
• W2079733906 modified "2023-09-24" @default.
• W2079733906 title "Comparison of Captopril and Enalapril in Patients with Severe Chronic Heart Failure" @default.
• W2079733906 cites W1966860295 @default.
• W2079733906 cites W1967896949 @default.
• W2079733906 cites W1980998139 @default.
• W2079733906 cites W1992407600 @default.
• W2079733906 cites W1997475982 @default.
• W2079733906 cites W1999369147 @default.
• W2079733906 cites W2006074028 @default.
• W2079733906 cites W2013966095 @default.
• W2079733906 cites W2018201359 @default.
• W2079733906 cites W2019791925 @default.
• W2079733906 cites W2025294328 @default.
• W2079733906 cites W2025570286 @default.
• W2079733906 cites W2026856301 @default.
• W2079733906 cites W2046947037 @default.
• W2079733906 cites W2051165221 @default.
• W2079733906 cites W2058095485 @default.
• W2079733906 cites W2063040213 @default.
• W2079733906 cites W2064113230 @default.
• W2079733906 cites W2077541147 @default.
• W2079733906 cites W2079280139 @default.
• W2079733906 cites W2081536241 @default.
• W2079733906 cites W2083945596 @default.
• W2079733906 cites W2088901044 @default.
• W2079733906 cites W2090289849 @default.
• W2079733906 cites W2092021737 @default.
• W2079733906 cites W2103673693 @default.
• W2079733906 cites W2122553381 @default.
• W2079733906 cites W2140587464 @default.
• W2079733906 cites W2159096663 @default.
• W2079733906 cites W2166029232 @default.
• W2079733906 cites W2166507721 @default.
• W2079733906 cites W2172225485 @default.
• W2079733906 cites W4210336424 @default.
• W2079733906 cites W4320300920 @default.
• W2079733906 doi "https://doi.org/10.1056/nejm198610023151402" @default.
• W2079733906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3018566" @default.
• W2079733906 hasPublicationYear "1986" @default.
• W2079733906 type Work @default.
• W2079733906 sameAs 2079733906 @default.
• W2079733906 citedByCount "273" @default.
• W2079733906 countsByYear W20797339062015 @default.
• W2079733906 countsByYear W20797339062016 @default.
• W2079733906 countsByYear W20797339062019 @default.
• W2079733906 countsByYear W20797339062020 @default.
• W2079733906 countsByYear W20797339062021 @default.
• W2079733906 crossrefType "journal-article" @default.
• W2079733906 hasAuthorship W2079733906A5022643632 @default.
• W2079733906 hasAuthorship W2079733906A5026223939 @default.
• W2079733906 hasAuthorship W2079733906A5028128654 @default.
• W2079733906 hasAuthorship W2079733906A5042766753 @default.
• W2079733906 hasConcept C126322002 @default.
• W2079733906 hasConcept C164705383 @default.
• W2079733906 hasConcept C27016395 @default.
• W2079733906 hasConcept C2775940317 @default.
• W2079733906 hasConcept C2777707475 @default.
• W2079733906 hasConcept C2778198053 @default.
• W2079733906 hasConcept C2779479957 @default.
• W2079733906 hasConcept C2779611605 @default.
• W2079733906 hasConcept C42219234 @default.
• W2079733906 hasConcept C71924100 @default.
• W2079733906 hasConcept C84393581 @default.
• W2079733906 hasConceptScore W2079733906C126322002 @default.
• W2079733906 hasConceptScore W2079733906C164705383 @default.
• W2079733906 hasConceptScore W2079733906C27016395 @default.
• W2079733906 hasConceptScore W2079733906C2775940317 @default.
• W2079733906 hasConceptScore W2079733906C2777707475 @default.
• W2079733906 hasConceptScore W2079733906C2778198053 @default.
• W2079733906 hasConceptScore W2079733906C2779479957 @default.
• W2079733906 hasConceptScore W2079733906C2779611605 @default.
• W2079733906 hasConceptScore W2079733906C42219234 @default.
• W2079733906 hasConceptScore W2079733906C71924100 @default.
• W2079733906 hasConceptScore W2079733906C84393581 @default.
• W2079733906 hasIssue "14" @default.
• W2079733906 hasLocation W20797339061 @default.
• W2079733906 hasLocation W20797339062 @default.
• W2079733906 hasOpenAccess W2079733906 @default.
• W2079733906 hasPrimaryLocation W20797339061 @default.
• W2079733906 hasRelatedWork W2056493235 @default.
• W2079733906 hasRelatedWork W2079733906 @default.
• W2079733906 hasRelatedWork W2084223257 @default.
• W2079733906 hasRelatedWork W2157965205 @default.
• W2079733906 hasRelatedWork W22745184 @default.
• W2079733906 hasRelatedWork W2413380006 @default.
• W2079733906 hasRelatedWork W2522552519 @default.
• W2079733906 hasRelatedWork W4235774201 @default.
• W2079733906 hasRelatedWork W4251819965 @default.
• W2079733906 hasRelatedWork W2417539937 @default.
• W2079733906 hasVolume "315" @default.
• W2079733906 isParatext "false" @default.

• next