FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079737710> ?p ?o ?g. }

• W2079737710 abstract "The Na+ and K+ permeability properties of rat brain mitochondria were determined to explain the influences of these cations upon respiration. A new procedure for isolating exceptionally intact mitochondria with minimal contamination by synaptosomes was developed for this purpose. Respiration was uncoupled by Na+ and less so by K+. Uncoupling was maximal in the presence of EDTA plus Pi and was decreased by Mg2+. Maximal uncoupler-stimulated respiration rates were inhibited by Na+ but largely unaffected by K+. The inhibition by Na+ was relatively insensitive to Mg2+. Membrane Na+ and K+ conductances as well as neutral exchanges (Na+/H+ and K+/H+ antiport activities) were determined by swelling measurements and correlated with metabolic effects of the cations. Cation conductance, i.e. electrophoretic Na+ or K+ permeation, was increased by EDTA (Na+ greater than K+) and decreased by Mg2+. Magnesium preferentially suppressed Na+ conductance so as to reverse the cation selectivity (K+ greater than Na+). Neutral cation/H+ exchange rates (Na+ greater than K+) were not influenced by chelator or Mg2+. The extent of cation-dependent uncoupling of respiration correlated best with the inner membrane conductance of the ion according to an empirical relationship derived with the model K+ conductor valinomycin. The metabolic influences of Na+ and K+ can be explained in terms of coupled flow of these ions with protons and their effect upon the H+ electrochemical gradient although alternative possibilities are discussed. These in vitro studies are compared to previous observations in situ to assess their physiological significance." @default.
• W2079737710 created "2016-06-24" @default.
• W2079737710 creator A5007939919 @default.
• W2079737710 creator A5022480367 @default.
• W2079737710 date "1979-11-01" @default.
• W2079737710 modified "2023-09-27" @default.
• W2079737710 title "The respiration of brain mitochondria and its regulation by monovalent cation transport" @default.
• W2079737710 cites W10497923 @default.
• W2079737710 cites W117433687 @default.
• W2079737710 cites W1484478520 @default.
• W2079737710 cites W1486293218 @default.
• W2079737710 cites W1500700435 @default.
• W2079737710 cites W1511109036 @default.
• W2079737710 cites W1587157283 @default.
• W2079737710 cites W1607058339 @default.
• W2079737710 cites W1775749144 @default.
• W2079737710 cites W1821786860 @default.
• W2079737710 cites W18625067 @default.
• W2079737710 cites W1931613501 @default.
• W2079737710 cites W1965800513 @default.
• W2079737710 cites W1974090212 @default.
• W2079737710 cites W1981363783 @default.
• W2079737710 cites W2014760103 @default.
• W2079737710 cites W2022421529 @default.
• W2079737710 cites W2024039200 @default.
• W2079737710 cites W2027061814 @default.
• W2079737710 cites W2027603335 @default.
• W2079737710 cites W2029028866 @default.
• W2079737710 cites W2037968674 @default.
• W2079737710 cites W2040174928 @default.
• W2079737710 cites W2041589971 @default.
• W2079737710 cites W2057162955 @default.
• W2079737710 cites W2060316913 @default.
• W2079737710 cites W2064222324 @default.
• W2079737710 cites W2067736707 @default.
• W2079737710 cites W2070666029 @default.
• W2079737710 cites W2070672868 @default.
• W2079737710 cites W2072023350 @default.
• W2079737710 cites W2076607275 @default.
• W2079737710 cites W2077996001 @default.
• W2079737710 cites W2080047780 @default.
• W2079737710 cites W208010609 @default.
• W2079737710 cites W2080482923 @default.
• W2079737710 cites W2085554856 @default.
• W2079737710 cites W2091357209 @default.
• W2079737710 cites W2104238407 @default.
• W2079737710 cites W2153435210 @default.
• W2079737710 cites W2344532313 @default.
• W2079737710 cites W2403099161 @default.
• W2079737710 cites W3109127821 @default.
• W2079737710 doi "https://doi.org/10.1016/0005-2728(79)90127-0" @default.
• W2079737710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/116678" @default.
• W2079737710 hasPublicationYear "1979" @default.
• W2079737710 type Work @default.
• W2079737710 sameAs 2079737710 @default.
• W2079737710 citedByCount "23" @default.
• W2079737710 crossrefType "journal-article" @default.
• W2079737710 hasAuthorship W2079737710A5007939919 @default.
• W2079737710 hasAuthorship W2079737710A5022480367 @default.
• W2079737710 hasConcept C105702510 @default.
• W2079737710 hasConcept C114614502 @default.
• W2079737710 hasConcept C121932024 @default.
• W2079737710 hasConcept C12554922 @default.
• W2079737710 hasConcept C178790620 @default.
• W2079737710 hasConcept C179104552 @default.
• W2079737710 hasConcept C181911157 @default.
• W2079737710 hasConcept C182215343 @default.
• W2079737710 hasConcept C185592680 @default.
• W2079737710 hasConcept C2778385715 @default.
• W2079737710 hasConcept C28859421 @default.
• W2079737710 hasConcept C33923547 @default.
• W2079737710 hasConcept C41625074 @default.
• W2079737710 hasConcept C543218039 @default.
• W2079737710 hasConcept C55493867 @default.
• W2079737710 hasConcept C57181701 @default.
• W2079737710 hasConcept C86803240 @default.
• W2079737710 hasConcept C99975950 @default.
• W2079737710 hasConceptScore W2079737710C105702510 @default.
• W2079737710 hasConceptScore W2079737710C114614502 @default.
• W2079737710 hasConceptScore W2079737710C121932024 @default.
• W2079737710 hasConceptScore W2079737710C12554922 @default.
• W2079737710 hasConceptScore W2079737710C178790620 @default.
• W2079737710 hasConceptScore W2079737710C179104552 @default.
• W2079737710 hasConceptScore W2079737710C181911157 @default.
• W2079737710 hasConceptScore W2079737710C182215343 @default.
• W2079737710 hasConceptScore W2079737710C185592680 @default.
• W2079737710 hasConceptScore W2079737710C2778385715 @default.
• W2079737710 hasConceptScore W2079737710C28859421 @default.
• W2079737710 hasConceptScore W2079737710C33923547 @default.
• W2079737710 hasConceptScore W2079737710C41625074 @default.
• W2079737710 hasConceptScore W2079737710C543218039 @default.
• W2079737710 hasConceptScore W2079737710C55493867 @default.
• W2079737710 hasConceptScore W2079737710C57181701 @default.
• W2079737710 hasConceptScore W2079737710C86803240 @default.
• W2079737710 hasConceptScore W2079737710C99975950 @default.
• W2079737710 hasLocation W20797377101 @default.
• W2079737710 hasLocation W20797377102 @default.
• W2079737710 hasOpenAccess W2079737710 @default.
• W2079737710 hasPrimaryLocation W20797377101 @default.
• W2079737710 hasRelatedWork W1590271961 @default.

• next