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- W2079738679 abstract "Currently available calcium antagonists act primarily on L-type calcium channels. Composed of 5 subunits, this ion channel is markedly more complicated than the potassium and sodium channels. Most of the data that have emerged over the past year have concerned the α subunit. The secondary structure of this subunit includes 4 repeating motifs; each motif contains 6 membrane-spanning helices, designated S1 through S6. The dihydropyridine (e.g., nifedipine) binding site is most likely situated primarily in motif 4 and the phenylalkylamine (e.g., verapamil) binding site is on motif 4 in an intracellular region. The benzothiazepine (e.g., diltiazem) binding site is also located on the α1 subunit, but its precise location has not been determined. The transmembrane helices S5 and S6 of each motif have been proposed as the “wall” of the actual ion channel." @default.
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- W2079738679 title "Molecular studies of the calcium antagonist binding site on calcium channels" @default.
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- W2079738679 doi "https://doi.org/10.1016/0002-9149(94)90259-3" @default.
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