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• W2079739714 endingPage "396" @default.
• W2079739714 startingPage "389" @default.
• W2079739714 abstract "The nematode Caenorhabditis elegans has been a powerful model system for biomedical research in the past decades, however, the efficient genetic tools are still demanding for gene knockout, knock-in or conditional gene mutations. Transcription activator-like effector nucleases (TALENs) that comprise a sequence-specific DNA-binding domain fused to a FokI nuclease domain facilitate the targeted genome editing in various cell types or organisms. Here we summarize the recent progresses and protocols using TALENs in C. elegans that generate gene mutations and knock-ins in the germ line and the conditional gene knockout in somatic tissues." @default.
• W2079739714 created "2016-06-24" @default.
• W2079739714 creator A5022148398 @default.
• W2079739714 creator A5077198827 @default.
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• W2079739714 date "2014-08-01" @default.
• W2079739714 modified "2023-09-27" @default.
• W2079739714 title "The application of transcription activator-like effector nucleases for genome editing in C. elegans" @default.
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• W2079739714 doi "https://doi.org/10.1016/j.ymeth.2014.04.013" @default.
• W2079739714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24780522" @default.
• W2079739714 hasPublicationYear "2014" @default.
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