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- W2079741056 abstract "The in vitro adsorption of quinidine sulphate on some commercial antacid and antidiarrhoeal preparations was assessed; the effect of some of these admixtures on drug absorption in human bioavailability studies was also measured using salivary secretion data. The adsorption of quinidine on Kaopectate (kaolin-pectin suspension) (25.8 mg/g) and magnesium-trisilicate (23.6 mg/g) was greater than that on Simeco tablets (aluminium hydroxide, magnesium carbonate and hydroxide, simethicone) (5.8 mg/g) or bismuth subnitrate (3.3 mg/g). Salivary quinidine concentrations decreased by 54% and the AUT by 58%, compared with control data, during the quinidine-Kaopectate interaction in vivo. This latter finding suggests a need for clinical monitoring of patients taking quinidine concomitantly with this type of adsorbent-antacid-antidiarrhoeal formulation." @default.
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- W2079741056 date "1987-01-01" @default.
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- W2079741056 title "Decreased bioavailability of quinidine sulphate due to interactions with adsorbent antacids and antidiarrhoeal mixtures" @default.
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