FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079741358> ?p ?o ?g. }

• W2079741358 abstract "Tortuous blood vessels are often seen in humans in association with thrombosis, atherosclerosis, hypertension, and aging. Vessel tortuosity can cause high fluid shear stress, likely promoting thrombosis. However, the underlying physical mechanisms and microscale processes are poorly understood. Accordingly, the objectives of this study were to develop and use a new computational approach to determine the effects of venule tortuosity and fluid velocity on thrombus initiation. The transport, collision, shear-induced activation, and receptor-ligand adhesion of individual platelets in thrombus formation were simulated using discrete element method. The shear-induced activation model assumed that a platelet became activated if it experienced a shear stress above a relative critical shear stress or if it contacted an activated platelet. Venules of various levels of tortuosity were simulated for a mean flow velocity of 0.10 cm s−1, and a tortuous arteriole was simulated for a mean velocity of 0.47 cm s−1. Our results showed that thrombus was initiated at inner walls in curved regions due to platelet activation in agreement with experimental studies. Increased venule tortuosity modified fluid flow to hasten thrombus initiation. Compared to the same sized venule, flow in the arteriole generated a higher amount of mural thrombi and platelet activation rate. The results suggest that the extent of tortuosity is an important factor in thrombus initiation in microvessels." @default.
• W2079741358 created "2016-06-24" @default.
• W2079741358 creator A5054753371 @default.
• W2079741358 creator A5058317572 @default.
• W2079741358 date "2011-12-01" @default.
• W2079741358 modified "2023-09-26" @default.
• W2079741358 title "Tortuosity Triggers Platelet Activation and Thrombus Formation in Microvessels" @default.
• W2079741358 cites W1572266937 @default.
• W2079741358 cites W1963549684 @default.
• W2079741358 cites W1967087511 @default.
• W2079741358 cites W1969287097 @default.
• W2079741358 cites W1975239679 @default.
• W2079741358 cites W1976503053 @default.
• W2079741358 cites W1976645945 @default.
• W2079741358 cites W1978378086 @default.
• W2079741358 cites W1984628949 @default.
• W2079741358 cites W1985187618 @default.
• W2079741358 cites W1988542482 @default.
• W2079741358 cites W1993622985 @default.
• W2079741358 cites W1999244633 @default.
• W2079741358 cites W1999923774 @default.
• W2079741358 cites W2000837049 @default.
• W2079741358 cites W2005172939 @default.
• W2079741358 cites W2005708795 @default.
• W2079741358 cites W2006308571 @default.
• W2079741358 cites W2007243735 @default.
• W2079741358 cites W2009917094 @default.
• W2079741358 cites W2011338555 @default.
• W2079741358 cites W2012049557 @default.
• W2079741358 cites W2019633776 @default.
• W2079741358 cites W2023052254 @default.
• W2079741358 cites W2024314380 @default.
• W2079741358 cites W2028133390 @default.
• W2079741358 cites W2029535745 @default.
• W2079741358 cites W2030181238 @default.
• W2079741358 cites W2030256176 @default.
• W2079741358 cites W2031159210 @default.
• W2079741358 cites W2034505774 @default.
• W2079741358 cites W2044806412 @default.
• W2079741358 cites W2049189170 @default.
• W2079741358 cites W2052192720 @default.
• W2079741358 cites W2056530098 @default.
• W2079741358 cites W2060539584 @default.
• W2079741358 cites W2085564020 @default.
• W2079741358 cites W2088295233 @default.
• W2079741358 cites W2089162734 @default.
• W2079741358 cites W2092434921 @default.
• W2079741358 cites W2099402325 @default.
• W2079741358 cites W2106339559 @default.
• W2079741358 cites W2109761253 @default.
• W2079741358 cites W2112518573 @default.
• W2079741358 cites W2112887261 @default.
• W2079741358 cites W2128493116 @default.
• W2079741358 cites W2129447163 @default.
• W2079741358 cites W2129617136 @default.
• W2079741358 cites W2133370274 @default.
• W2079741358 cites W2134785906 @default.
• W2079741358 cites W2146121506 @default.
• W2079741358 cites W2146202010 @default.
• W2079741358 cites W2149038729 @default.
• W2079741358 cites W2159942139 @default.
• W2079741358 cites W2161980036 @default.
• W2079741358 cites W2168575889 @default.
• W2079741358 cites W2170214799 @default.
• W2079741358 cites W4250669841 @default.
• W2079741358 doi "https://doi.org/10.1115/1.4005478" @default.
• W2079741358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3489919" @default.
• W2079741358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22206421" @default.
• W2079741358 hasPublicationYear "2011" @default.
• W2079741358 type Work @default.
• W2079741358 sameAs 2079741358 @default.
• W2079741358 citedByCount "47" @default.
• W2079741358 countsByYear W20797413582012 @default.
• W2079741358 countsByYear W20797413582013 @default.
• W2079741358 countsByYear W20797413582014 @default.
• W2079741358 countsByYear W20797413582015 @default.
• W2079741358 countsByYear W20797413582016 @default.
• W2079741358 countsByYear W20797413582017 @default.
• W2079741358 countsByYear W20797413582018 @default.
• W2079741358 countsByYear W20797413582019 @default.
• W2079741358 countsByYear W20797413582020 @default.
• W2079741358 countsByYear W20797413582021 @default.
• W2079741358 countsByYear W20797413582022 @default.
• W2079741358 countsByYear W20797413582023 @default.
• W2079741358 crossrefType "journal-article" @default.
• W2079741358 hasAuthorship W2079741358A5054753371 @default.
• W2079741358 hasAuthorship W2079741358A5058317572 @default.
• W2079741358 hasBestOaLocation W20797413582 @default.
• W2079741358 hasConcept C126322002 @default.
• W2079741358 hasConcept C12722491 @default.
• W2079741358 hasConcept C159985019 @default.
• W2079741358 hasConcept C164705383 @default.
• W2079741358 hasConcept C185250623 @default.
• W2079741358 hasConcept C185592680 @default.
• W2079741358 hasConcept C192562407 @default.
• W2079741358 hasConcept C21141959 @default.
• W2079741358 hasConcept C2776992346 @default.
• W2079741358 hasConcept C2778672379 @default.
• W2079741358 hasConcept C2779482390 @default.
• W2079741358 hasConcept C2780868729 @default.

• next