Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079741709> ?p ?o ?g. }
- W2079741709 endingPage "9159" @default.
- W2079741709 startingPage "9154" @default.
- W2079741709 abstract "DNA lesions that arrest replication can lead to rearrangements, mutations, or lethality when not processed accurately. After UV-induced DNA damage in Escherichia coli , RecA and several recF pathway proteins are thought to process arrested replication forks and ensure that replication resumes accurately. Here, we show that the RecJ nuclease and RecQ helicase, which partially degrade the nascent DNA at blocked replication forks, are required for the rapid recovery of DNA synthesis and prevent the potentially mutagenic bypass of UV lesions. In the absence of RecJ, or to a lesser extent RecQ, the recovery of replication is significantly delayed, and both the recovery and cell survival become dependent on translesion synthesis by polymerase V. The RecJ-mediated processing is proposed to restore the region containing the lesion to a form that allows repair enzymes to remove the blocking lesion and DNA synthesis to resume. In the absence of nascent DNA processing, polymerase V can synthesize past the lesion to prevent lethality, although this occurs with slower kinetics and a higher frequency of mutagenesis." @default.
- W2079741709 created "2016-06-24" @default.
- W2079741709 creator A5013252820 @default.
- W2079741709 creator A5024620549 @default.
- W2079741709 creator A5042704409 @default.
- W2079741709 creator A5070605555 @default.
- W2079741709 date "2006-06-13" @default.
- W2079741709 modified "2023-10-01" @default.
- W2079741709 title "Nascent DNA processing by RecJ favors lesion repair over translesion synthesis at arrested replication forks in <i>Escherichia coli</i>" @default.
- W2079741709 cites W1510371408 @default.
- W2079741709 cites W1524720546 @default.
- W2079741709 cites W1825077011 @default.
- W2079741709 cites W1843973938 @default.
- W2079741709 cites W1854173852 @default.
- W2079741709 cites W1881339298 @default.
- W2079741709 cites W1926322311 @default.
- W2079741709 cites W1960608041 @default.
- W2079741709 cites W1964111587 @default.
- W2079741709 cites W1968724116 @default.
- W2079741709 cites W1972522403 @default.
- W2079741709 cites W1972974900 @default.
- W2079741709 cites W1973154704 @default.
- W2079741709 cites W1977518145 @default.
- W2079741709 cites W1984459901 @default.
- W2079741709 cites W1987914894 @default.
- W2079741709 cites W1989798735 @default.
- W2079741709 cites W1995004577 @default.
- W2079741709 cites W2000709611 @default.
- W2079741709 cites W2001861614 @default.
- W2079741709 cites W2002333699 @default.
- W2079741709 cites W2006646718 @default.
- W2079741709 cites W2013310168 @default.
- W2079741709 cites W2014442287 @default.
- W2079741709 cites W2016430241 @default.
- W2079741709 cites W2019391749 @default.
- W2079741709 cites W2032004743 @default.
- W2079741709 cites W2034023949 @default.
- W2079741709 cites W2041166332 @default.
- W2079741709 cites W2042902860 @default.
- W2079741709 cites W2054129096 @default.
- W2079741709 cites W2083123225 @default.
- W2079741709 cites W2085866527 @default.
- W2079741709 cites W2092527060 @default.
- W2079741709 cites W2093679000 @default.
- W2079741709 cites W2099958026 @default.
- W2079741709 cites W2114809602 @default.
- W2079741709 cites W2115952866 @default.
- W2079741709 cites W2119626376 @default.
- W2079741709 cites W2132953534 @default.
- W2079741709 cites W2137227311 @default.
- W2079741709 cites W2137358848 @default.
- W2079741709 cites W2138190884 @default.
- W2079741709 cites W2142618175 @default.
- W2079741709 cites W2153418663 @default.
- W2079741709 cites W2313046319 @default.
- W2079741709 doi "https://doi.org/10.1073/pnas.0600785103" @default.
- W2079741709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1482582" @default.
- W2079741709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16754873" @default.
- W2079741709 hasPublicationYear "2006" @default.
- W2079741709 type Work @default.
- W2079741709 sameAs 2079741709 @default.
- W2079741709 citedByCount "84" @default.
- W2079741709 countsByYear W20797417092012 @default.
- W2079741709 countsByYear W20797417092013 @default.
- W2079741709 countsByYear W20797417092014 @default.
- W2079741709 countsByYear W20797417092015 @default.
- W2079741709 countsByYear W20797417092016 @default.
- W2079741709 countsByYear W20797417092017 @default.
- W2079741709 countsByYear W20797417092018 @default.
- W2079741709 countsByYear W20797417092019 @default.
- W2079741709 countsByYear W20797417092021 @default.
- W2079741709 countsByYear W20797417092022 @default.
- W2079741709 countsByYear W20797417092023 @default.
- W2079741709 crossrefType "journal-article" @default.
- W2079741709 hasAuthorship W2079741709A5013252820 @default.
- W2079741709 hasAuthorship W2079741709A5024620549 @default.
- W2079741709 hasAuthorship W2079741709A5042704409 @default.
- W2079741709 hasAuthorship W2079741709A5070605555 @default.
- W2079741709 hasBestOaLocation W20797417091 @default.
- W2079741709 hasConcept C104317684 @default.
- W2079741709 hasConcept C104690221 @default.
- W2079741709 hasConcept C113271649 @default.
- W2079741709 hasConcept C134935766 @default.
- W2079741709 hasConcept C143425029 @default.
- W2079741709 hasConcept C153911025 @default.
- W2079741709 hasConcept C161223559 @default.
- W2079741709 hasConcept C16318435 @default.
- W2079741709 hasConcept C167975912 @default.
- W2079741709 hasConcept C178169997 @default.
- W2079741709 hasConcept C2756471 @default.
- W2079741709 hasConcept C2780751114 @default.
- W2079741709 hasConcept C501734568 @default.
- W2079741709 hasConcept C552990157 @default.
- W2079741709 hasConcept C55493867 @default.
- W2079741709 hasConcept C64241487 @default.
- W2079741709 hasConcept C67705224 @default.
- W2079741709 hasConcept C73573662 @default.
- W2079741709 hasConcept C82381507 @default.