FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079742755> ?p ?o ?g. }

• W2079742755 endingPage "4507" @default.
• W2079742755 startingPage "4501" @default.
• W2079742755 abstract "A recent clinical trial of a live-attenuated tetravalent chimeric yellow fever-dengue vaccine afforded no protection against disease caused by dengue 2 (DENV-2). This outcome was unexpected as two or more doses of this vaccine had raised broad neutralizing antibody responses. Data from pre-clinical subhuman primate studies revealed that vaccination with the monotypic DENV-2 component failed to meet established criteria for solid protection to homotypic live virus challenge. Accordingly, it is suggested that preclinical testing adopt more rigorous criteria for protection and that Phase I testing be extended to require evidence of solid monotypic protective immunity for each component of a dengue vaccine by direct challenge with live-attenuated DENV. Because live-attenuated tetravalent DENV vaccines exhibit evidence of immunological interference phenomena, during Phase II, volunteers given mixtures of DENV 1–4 vaccines should be separately challenged with monotypic live-attenuated DENV. Immune responses to live-attenuated challenge viruses and vaccine strains should be studied in an attempt to develop useful in vitro correlates of in vivo protection. Finally, it will be important to learn if DENV non-structural protein 1 (NS1) contributes to pathogenesis of the vascular permeability syndrome in humans. If so, immunity to dengue 1–4 NS1 may be crucial to prevent severe disease." @default.
• W2079742755 created "2016-06-24" @default.
• W2079742755 creator A5077156970 @default.
• W2079742755 date "2013-09-01" @default.
• W2079742755 modified "2023-09-27" @default.
• W2079742755 title "Identifying protective dengue vaccines: Guide to mastering an empirical process" @default.
• W2079742755 cites W1623942788 @default.
• W2079742755 cites W1822185265 @default.
• W2079742755 cites W1827712740 @default.
• W2079742755 cites W1879379129 @default.
• W2079742755 cites W1895662328 @default.
• W2079742755 cites W1913165748 @default.
• W2079742755 cites W1922871278 @default.
• W2079742755 cites W1942194807 @default.
• W2079742755 cites W1945551713 @default.
• W2079742755 cites W1972571303 @default.
• W2079742755 cites W1980444528 @default.
• W2079742755 cites W1981511899 @default.
• W2079742755 cites W1981895261 @default.
• W2079742755 cites W1987580985 @default.
• W2079742755 cites W1997329577 @default.
• W2079742755 cites W2002955611 @default.
• W2079742755 cites W2011180876 @default.
• W2079742755 cites W2017258497 @default.
• W2079742755 cites W2017577931 @default.
• W2079742755 cites W2023010141 @default.
• W2079742755 cites W2036358030 @default.
• W2079742755 cites W2039707046 @default.
• W2079742755 cites W2039781676 @default.
• W2079742755 cites W2040288464 @default.
• W2079742755 cites W2044816964 @default.
• W2079742755 cites W2046222540 @default.
• W2079742755 cites W2059763682 @default.
• W2079742755 cites W2062787065 @default.
• W2079742755 cites W2065952556 @default.
• W2079742755 cites W2080387988 @default.
• W2079742755 cites W2086101483 @default.
• W2079742755 cites W2086448648 @default.
• W2079742755 cites W2093844440 @default.
• W2079742755 cites W2095340306 @default.
• W2079742755 cites W2097288560 @default.
• W2079742755 cites W2099694719 @default.
• W2079742755 cites W2103904170 @default.
• W2079742755 cites W2111222009 @default.
• W2079742755 cites W2111616439 @default.
• W2079742755 cites W2112175485 @default.
• W2079742755 cites W2113583073 @default.
• W2079742755 cites W2113785436 @default.
• W2079742755 cites W2114467541 @default.
• W2079742755 cites W2115006973 @default.
• W2079742755 cites W2121368175 @default.
• W2079742755 cites W2124657746 @default.
• W2079742755 cites W2131377273 @default.
• W2079742755 cites W2131753358 @default.
• W2079742755 cites W2134761981 @default.
• W2079742755 cites W2134850550 @default.
• W2079742755 cites W2135614333 @default.
• W2079742755 cites W2138507390 @default.
• W2079742755 cites W2139197205 @default.
• W2079742755 cites W2140139336 @default.
• W2079742755 cites W2144902263 @default.
• W2079742755 cites W2146980643 @default.
• W2079742755 cites W2148802878 @default.
• W2079742755 cites W2150870631 @default.
• W2079742755 cites W2153930618 @default.
• W2079742755 cites W2154248797 @default.
• W2079742755 cites W2162674618 @default.
• W2079742755 cites W2168392705 @default.
• W2079742755 cites W2171775334 @default.
• W2079742755 cites W2172031283 @default.
• W2079742755 cites W2274083554 @default.
• W2079742755 cites W2466252332 @default.
• W2079742755 cites W2749102845 @default.
• W2079742755 cites W4241508272 @default.
• W2079742755 doi "https://doi.org/10.1016/j.vaccine.2013.06.079" @default.
• W2079742755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23896423" @default.
• W2079742755 hasPublicationYear "2013" @default.
• W2079742755 type Work @default.
• W2079742755 sameAs 2079742755 @default.
• W2079742755 citedByCount "100" @default.
• W2079742755 countsByYear W20797427552013 @default.
• W2079742755 countsByYear W20797427552014 @default.
• W2079742755 countsByYear W20797427552015 @default.
• W2079742755 countsByYear W20797427552016 @default.
• W2079742755 countsByYear W20797427552017 @default.
• W2079742755 countsByYear W20797427552018 @default.
• W2079742755 countsByYear W20797427552019 @default.
• W2079742755 countsByYear W20797427552020 @default.
• W2079742755 countsByYear W20797427552022 @default.
• W2079742755 countsByYear W20797427552023 @default.
• W2079742755 crossrefType "journal-article" @default.
• W2079742755 hasAuthorship W2079742755A5077156970 @default.
• W2079742755 hasBestOaLocation W20797427551 @default.
• W2079742755 hasConcept C104317684 @default.
• W2079742755 hasConcept C159047783 @default.
• W2079742755 hasConcept C203014093 @default.
• W2079742755 hasConcept C22070199 @default.
• W2079742755 hasConcept C2779261636 @default.

• next