Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079746776> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079746776 endingPage "28" @default.
- W2079746776 startingPage "25" @default.
- W2079746776 abstract "The elution of antibiotics from hand mixed antibiotic-laden polymethylmethacrylate (PMMA) must be increased to achieve clinical performance equivalent to commercially manufactured antibiotic beads (not available in the USA) in the management of musculoskeletal infections. Adding fillers such as glycine and dextran to polymethylmethacrylate increases the elution of antibiotics from antibiotic-laden PMMA. We propose xylitol, a naturally occurring sweetener with direct antibiofilm properties, as a filler material. To compare the efficacy of xylitol and glycine as fillers on the elution of antibiotics from PMMA, elution studies were performed on mixtures of Palacos® polymethylmethacrylate and daptomycin (1 gm) with xylitol or glycine as the filler (28 g). Xylitol and glycine enhanced the daptomycin activity eluted from the polymethylmethacrylate. Xylitol was more effective than glycine, having a greater increase in daptomycin release at all data points; on day one xylitol increased the elution of daptomycin 2.67 times whereas glycine increased it 1.78 times also on day one. The eluant concentration of daptomycin remained higher longer for xylitol; 3.90 μg/mL for xylitol versus 2.25 μg/mL for glycine on day 9. Xylitol is inexpensive and readily available. It can be hand mixed with PMMA, and is more effective than glycine as a filler to enhance daptomycin release. Considering possible antibiofilm activity, xylitol may be a more advantageous choice." @default.
- W2079746776 created "2016-06-24" @default.
- W2079746776 creator A5073221875 @default.
- W2079746776 creator A5075031124 @default.
- W2079746776 creator A5080424763 @default.
- W2079746776 date "2006-10-01" @default.
- W2079746776 modified "2023-10-15" @default.
- W2079746776 title "Xylitol and Glycine Fillers Increase Permeability of PMMA to Enhance Elution of Daptomycin" @default.
- W2079746776 cites W15735126 @default.
- W2079746776 cites W1862412800 @default.
- W2079746776 cites W1994652526 @default.
- W2079746776 cites W1998367037 @default.
- W2079746776 cites W2051272201 @default.
- W2079746776 cites W2053438384 @default.
- W2079746776 cites W2068240651 @default.
- W2079746776 cites W2071364349 @default.
- W2079746776 cites W2079172396 @default.
- W2079746776 cites W2154246859 @default.
- W2079746776 cites W2334562157 @default.
- W2079746776 doi "https://doi.org/10.1097/01.blo.0000229321.53040.a1" @default.
- W2079746776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16906079" @default.
- W2079746776 hasPublicationYear "2006" @default.
- W2079746776 type Work @default.
- W2079746776 sameAs 2079746776 @default.
- W2079746776 citedByCount "44" @default.
- W2079746776 countsByYear W20797467762012 @default.
- W2079746776 countsByYear W20797467762013 @default.
- W2079746776 countsByYear W20797467762014 @default.
- W2079746776 countsByYear W20797467762015 @default.
- W2079746776 countsByYear W20797467762016 @default.
- W2079746776 countsByYear W20797467762017 @default.
- W2079746776 countsByYear W20797467762019 @default.
- W2079746776 countsByYear W20797467762020 @default.
- W2079746776 countsByYear W20797467762021 @default.
- W2079746776 countsByYear W20797467762022 @default.
- W2079746776 crossrefType "journal-article" @default.
- W2079746776 hasAuthorship W2079746776A5073221875 @default.
- W2079746776 hasAuthorship W2079746776A5075031124 @default.
- W2079746776 hasAuthorship W2079746776A5080424763 @default.
- W2079746776 hasConcept C100544194 @default.
- W2079746776 hasConcept C185592680 @default.
- W2079746776 hasConcept C2776031079 @default.
- W2079746776 hasConcept C2777756961 @default.
- W2079746776 hasConcept C2778651397 @default.
- W2079746776 hasConcept C2778980435 @default.
- W2079746776 hasConcept C2779489039 @default.
- W2079746776 hasConcept C31903555 @default.
- W2079746776 hasConcept C43617362 @default.
- W2079746776 hasConcept C501593827 @default.
- W2079746776 hasConcept C515207424 @default.
- W2079746776 hasConcept C523546767 @default.
- W2079746776 hasConcept C54355233 @default.
- W2079746776 hasConcept C55493867 @default.
- W2079746776 hasConcept C71924100 @default.
- W2079746776 hasConcept C73826308 @default.
- W2079746776 hasConcept C86803240 @default.
- W2079746776 hasConceptScore W2079746776C100544194 @default.
- W2079746776 hasConceptScore W2079746776C185592680 @default.
- W2079746776 hasConceptScore W2079746776C2776031079 @default.
- W2079746776 hasConceptScore W2079746776C2777756961 @default.
- W2079746776 hasConceptScore W2079746776C2778651397 @default.
- W2079746776 hasConceptScore W2079746776C2778980435 @default.
- W2079746776 hasConceptScore W2079746776C2779489039 @default.
- W2079746776 hasConceptScore W2079746776C31903555 @default.
- W2079746776 hasConceptScore W2079746776C43617362 @default.
- W2079746776 hasConceptScore W2079746776C501593827 @default.
- W2079746776 hasConceptScore W2079746776C515207424 @default.
- W2079746776 hasConceptScore W2079746776C523546767 @default.
- W2079746776 hasConceptScore W2079746776C54355233 @default.
- W2079746776 hasConceptScore W2079746776C55493867 @default.
- W2079746776 hasConceptScore W2079746776C71924100 @default.
- W2079746776 hasConceptScore W2079746776C73826308 @default.
- W2079746776 hasConceptScore W2079746776C86803240 @default.
- W2079746776 hasLocation W20797467761 @default.
- W2079746776 hasLocation W20797467762 @default.
- W2079746776 hasOpenAccess W2079746776 @default.
- W2079746776 hasPrimaryLocation W20797467761 @default.
- W2079746776 hasRelatedWork W1610022375 @default.
- W2079746776 hasRelatedWork W2136296616 @default.
- W2079746776 hasRelatedWork W2148026222 @default.
- W2079746776 hasRelatedWork W2155311152 @default.
- W2079746776 hasRelatedWork W2168625432 @default.
- W2079746776 hasRelatedWork W2183230822 @default.
- W2079746776 hasRelatedWork W2418051334 @default.
- W2079746776 hasRelatedWork W2582587270 @default.
- W2079746776 hasRelatedWork W2767493757 @default.
- W2079746776 hasRelatedWork W3033835965 @default.
- W2079746776 hasVolume "451" @default.
- W2079746776 isParatext "false" @default.
- W2079746776 isRetracted "false" @default.
- W2079746776 magId "2079746776" @default.
- W2079746776 workType "article" @default.