Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079748997> ?p ?o ?g. }
- W2079748997 endingPage "232" @default.
- W2079748997 startingPage "221" @default.
- W2079748997 abstract "Salmonella enterica uses effector proteins delivered by type III secretion systems (TTSS) to colonize eukaryotic cells. Recent in vivo studies have shown that intracellular bacteria activate the TTSS encoded by Salmonella pathogenicity island-2 (SPI-2) to restrain growth inside phagocytes. Growth attenuation is also observed in vivo in bacteria colonizing nonphagocytic stromal cells of the intestinal lamina propria and in cultured fibroblasts. SPI-2 is required for survival of nongrowing bacteria persisting inside fibroblasts, but its induction mode and the effectors involved remain unknown. Here, we show that nongrowing dormant intracellular bacteria use the two-component system OmpR-EnvZ to induce SPI-2 expression and the PhoP-PhoQ system to regulate the time at which induction takes place, 2 h postentry. Dormant bacteria were shown to discriminate the usage of SPI-2 effectors. Among the effectors tested, SseF, SseG, and SseJ were required for survival, while others, such as SifA and SifB, were not. SifA and SifB dispensability correlated with the inability of intracellular bacteria to secrete these effectors even when overexpressed. Conversely, SseJ overproduction resulted in augmented secretion and exacerbated bacterial growth. Dormant bacteria produced other effectors, such as PipB and PipB2, that, unlike what was reported for epithelial cells, did not to traffic outside the phagosomal compartment. Therefore, permissiveness for secreting only a subset of SPI-2 effectors may be instrumental for dormancy. We propose that the S. enterica serovar Typhimurium nonproliferative intracellular lifestyle is sustained by selection of SPI-2 effectors that are produced in tightly defined amounts and delivered to phagosome-confined locations." @default.
- W2079748997 created "2016-06-24" @default.
- W2079748997 creator A5006404066 @default.
- W2079748997 creator A5076644661 @default.
- W2079748997 creator A5076922456 @default.
- W2079748997 creator A5087276344 @default.
- W2079748997 creator A5087607394 @default.
- W2079748997 date "2014-01-01" @default.
- W2079748997 modified "2023-10-18" @default.
- W2079748997 title "Dormant Intracellular Salmonella enterica Serovar Typhimurium Discriminates among Salmonella Pathogenicity Island 2 Effectors To Persist inside Fibroblasts" @default.
- W2079748997 cites W1516924582 @default.
- W2079748997 cites W1533311582 @default.
- W2079748997 cites W1586518876 @default.
- W2079748997 cites W1655404396 @default.
- W2079748997 cites W1968426638 @default.
- W2079748997 cites W1968846062 @default.
- W2079748997 cites W1970934009 @default.
- W2079748997 cites W1975809728 @default.
- W2079748997 cites W1982119335 @default.
- W2079748997 cites W1983594570 @default.
- W2079748997 cites W1984967772 @default.
- W2079748997 cites W1988717370 @default.
- W2079748997 cites W1989630349 @default.
- W2079748997 cites W1996271564 @default.
- W2079748997 cites W2000672451 @default.
- W2079748997 cites W2004324618 @default.
- W2079748997 cites W2006968989 @default.
- W2079748997 cites W2007462124 @default.
- W2079748997 cites W2012611655 @default.
- W2079748997 cites W2014746756 @default.
- W2079748997 cites W2021071631 @default.
- W2079748997 cites W2036719198 @default.
- W2079748997 cites W2047067167 @default.
- W2079748997 cites W2049588263 @default.
- W2079748997 cites W2050479583 @default.
- W2079748997 cites W2053278708 @default.
- W2079748997 cites W2053631737 @default.
- W2079748997 cites W2056117178 @default.
- W2079748997 cites W2064619165 @default.
- W2079748997 cites W2069702624 @default.
- W2079748997 cites W2069745152 @default.
- W2079748997 cites W2071999738 @default.
- W2079748997 cites W2073864358 @default.
- W2079748997 cites W2075183011 @default.
- W2079748997 cites W2076997718 @default.
- W2079748997 cites W2079374141 @default.
- W2079748997 cites W2080033753 @default.
- W2079748997 cites W2081226705 @default.
- W2079748997 cites W2095782520 @default.
- W2079748997 cites W2097813770 @default.
- W2079748997 cites W2099291451 @default.
- W2079748997 cites W2101695227 @default.
- W2079748997 cites W2104474035 @default.
- W2079748997 cites W2105246389 @default.
- W2079748997 cites W2107062230 @default.
- W2079748997 cites W2107094749 @default.
- W2079748997 cites W2108337274 @default.
- W2079748997 cites W2111325445 @default.
- W2079748997 cites W2116089804 @default.
- W2079748997 cites W2117054496 @default.
- W2079748997 cites W2119464939 @default.
- W2079748997 cites W2121396317 @default.
- W2079748997 cites W2123680076 @default.
- W2079748997 cites W2125524847 @default.
- W2079748997 cites W2126996677 @default.
- W2079748997 cites W2127041383 @default.
- W2079748997 cites W2127697422 @default.
- W2079748997 cites W2135562678 @default.
- W2079748997 cites W2140162925 @default.
- W2079748997 cites W2141227785 @default.
- W2079748997 cites W2143398242 @default.
- W2079748997 cites W2144573392 @default.
- W2079748997 cites W2151264799 @default.
- W2079748997 cites W2158077160 @default.
- W2079748997 cites W2158715471 @default.
- W2079748997 cites W2159671439 @default.
- W2079748997 cites W2165036780 @default.
- W2079748997 cites W2167730443 @default.
- W2079748997 cites W2170484617 @default.
- W2079748997 cites W2170691213 @default.
- W2079748997 cites W4213353716 @default.
- W2079748997 cites W4245247839 @default.
- W2079748997 doi "https://doi.org/10.1128/iai.01304-13" @default.
- W2079748997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3911833" @default.
- W2079748997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24144726" @default.
- W2079748997 hasPublicationYear "2014" @default.
- W2079748997 type Work @default.
- W2079748997 sameAs 2079748997 @default.
- W2079748997 citedByCount "27" @default.
- W2079748997 countsByYear W20797489972014 @default.
- W2079748997 countsByYear W20797489972015 @default.
- W2079748997 countsByYear W20797489972016 @default.
- W2079748997 countsByYear W20797489972017 @default.
- W2079748997 countsByYear W20797489972018 @default.
- W2079748997 countsByYear W20797489972020 @default.
- W2079748997 countsByYear W20797489972021 @default.
- W2079748997 countsByYear W20797489972022 @default.
- W2079748997 countsByYear W20797489972023 @default.