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• W2079749767 abstract "Human fetal pancreata (HFP) were obtained from dilatation and extraction aborted fetuses of 11–18 weeks' gestation. The pancreas was excised under sterile conditions and kept in culture medium at 4 °C, prior to stepwise digestion into 50- to 150-μm fragments. The fragmented pieces were allowed to sediment by gravity, then transferred to tissue culture for 24–48 h, and cryopreserved. The freeze-thaw protocol used stepwise equilibration with dimethyl sulfoxide, nucleation of the sample at −10 °C, and a slow cooling rate of 0.25 °C/min to −40 °C, followed by submersion in liquid nitrogen (−196 °C). Rapid thawing at 300 °C/min from −196 °C was employed. Both fresh and frozen-thawed HFP fragments appeared viable as judged by light and electron microscopy, and secreted insulin in a perifusion system upon stimulation with glucose (28 mM) and theophylline (10 mM) or glucose (2.8 mM) and theophylline (10 mM). Six patients with Type I insulin-dependent diabetes mellitus, already requiring immunosuppression for a kidney transplant, had intraportal injection of 20 cryopreserved-thawed and pooled HFP fragments. Up to the 1-year post-transplant follow-up, there has been no evidence of in vivo insulin or C-peptide production. The usefulness of cryopreserved human fetal pancreata as a source of insulin-producing tissue for diabetic patients, therefore, remains to be demonstrated." @default.
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• W2079749767 date "1988-04-01" @default.
• W2079749767 modified "2023-10-16" @default.
• W2079749767 title "Cryopreserved human fetal pancreas: A source of insulin-producing tissue?" @default.
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• W2079749767 doi "https://doi.org/10.1016/0011-2240(88)90001-6" @default.
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