Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079751378> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2079751378 endingPage "88" @default.
- W2079751378 startingPage "76" @default.
- W2079751378 abstract "Twelve patients with congenital agammaglobulinemia, 2 of 10 patients with selective IgA deficiency, and 4 of 15 patients with common variable immunodeficiency have reduced 5′-nucleotidase activity on lymphocyte plasma membranes. In congenital agammaglobulinemia and common variable immunodeficiency, enzyme-deficient patients have an early onset of immune dysfunction, low levels or an absence of circulating B-lymphocytes, and a positive family history of similar immunodeficiency. The enzyme deficiency involves peripheral E-rosette-forming lymphocytes, suggesting an abnormality of T-lymphocytes in these diseases. No systemic disorder of purine nucleotide degradation to uric acid is detectable in the enzyme-deficient patients. No direct relationship between 5′-nucleotidase activity and in vitro production of IgG is evident, since inhibition of the enzyme did not decrease IgG synthesis. At present the data do not allow a distinction between two hypotheses to explain the role of 5′-nucleotidase in hypogamma-globulinemia, that is, whether 5′-nucleotidase deficiency causes the immune dysfunction or is simply a marker for an intrinsic lymphocyte abnormality. However, this enzyme deficiency may provide a useful means of classifying disorders of immunoglobulin synthesis." @default.
- W2079751378 created "2016-06-24" @default.
- W2079751378 creator A5005403102 @default.
- W2079751378 creator A5068729590 @default.
- W2079751378 creator A5088526246 @default.
- W2079751378 date "1980-09-01" @default.
- W2079751378 modified "2023-09-26" @default.
- W2079751378 title "Lymphocyte 5′-nucleotidase deficiency in hypogammaglobulinemia: Clinical characteristics" @default.
- W2079751378 cites W1507839279 @default.
- W2079751378 cites W1775749144 @default.
- W2079751378 cites W1971441325 @default.
- W2079751378 cites W1973304846 @default.
- W2079751378 cites W1974148619 @default.
- W2079751378 cites W1985342306 @default.
- W2079751378 cites W1992744181 @default.
- W2079751378 cites W1999516176 @default.
- W2079751378 cites W2009069048 @default.
- W2079751378 cites W2011375511 @default.
- W2079751378 cites W2014613440 @default.
- W2079751378 cites W2021181782 @default.
- W2079751378 cites W2034015730 @default.
- W2079751378 cites W2046507634 @default.
- W2079751378 cites W2071733704 @default.
- W2079751378 cites W2083111591 @default.
- W2079751378 cites W2084439632 @default.
- W2079751378 cites W2108652885 @default.
- W2079751378 cites W2119263245 @default.
- W2079751378 cites W2139727611 @default.
- W2079751378 cites W2145370011 @default.
- W2079751378 cites W2329211716 @default.
- W2079751378 cites W2465735835 @default.
- W2079751378 cites W28228218 @default.
- W2079751378 cites W991869517 @default.
- W2079751378 doi "https://doi.org/10.1016/0090-1229(80)90075-6" @default.
- W2079751378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6250749" @default.
- W2079751378 hasPublicationYear "1980" @default.
- W2079751378 type Work @default.
- W2079751378 sameAs 2079751378 @default.
- W2079751378 citedByCount "20" @default.
- W2079751378 crossrefType "journal-article" @default.
- W2079751378 hasAuthorship W2079751378A5005403102 @default.
- W2079751378 hasAuthorship W2079751378A5068729590 @default.
- W2079751378 hasAuthorship W2079751378A5088526246 @default.
- W2079751378 hasBestOaLocation W20797513782 @default.
- W2079751378 hasConcept C159654299 @default.
- W2079751378 hasConcept C181199279 @default.
- W2079751378 hasConcept C18880352 @default.
- W2079751378 hasConcept C203014093 @default.
- W2079751378 hasConcept C2776433325 @default.
- W2079751378 hasConcept C2777607303 @default.
- W2079751378 hasConcept C2777761686 @default.
- W2079751378 hasConcept C2777805810 @default.
- W2079751378 hasConcept C2777913276 @default.
- W2079751378 hasConcept C2779019163 @default.
- W2079751378 hasConcept C2780648854 @default.
- W2079751378 hasConcept C55493867 @default.
- W2079751378 hasConcept C71924100 @default.
- W2079751378 hasConcept C86803240 @default.
- W2079751378 hasConcept C8891405 @default.
- W2079751378 hasConceptScore W2079751378C159654299 @default.
- W2079751378 hasConceptScore W2079751378C181199279 @default.
- W2079751378 hasConceptScore W2079751378C18880352 @default.
- W2079751378 hasConceptScore W2079751378C203014093 @default.
- W2079751378 hasConceptScore W2079751378C2776433325 @default.
- W2079751378 hasConceptScore W2079751378C2777607303 @default.
- W2079751378 hasConceptScore W2079751378C2777761686 @default.
- W2079751378 hasConceptScore W2079751378C2777805810 @default.
- W2079751378 hasConceptScore W2079751378C2777913276 @default.
- W2079751378 hasConceptScore W2079751378C2779019163 @default.
- W2079751378 hasConceptScore W2079751378C2780648854 @default.
- W2079751378 hasConceptScore W2079751378C55493867 @default.
- W2079751378 hasConceptScore W2079751378C71924100 @default.
- W2079751378 hasConceptScore W2079751378C86803240 @default.
- W2079751378 hasConceptScore W2079751378C8891405 @default.
- W2079751378 hasIssue "1" @default.
- W2079751378 hasLocation W20797513781 @default.
- W2079751378 hasLocation W20797513782 @default.
- W2079751378 hasLocation W20797513783 @default.
- W2079751378 hasOpenAccess W2079751378 @default.
- W2079751378 hasPrimaryLocation W20797513781 @default.
- W2079751378 hasRelatedWork W1501814168 @default.
- W2079751378 hasRelatedWork W1506984959 @default.
- W2079751378 hasRelatedWork W174827180 @default.
- W2079751378 hasRelatedWork W1915809870 @default.
- W2079751378 hasRelatedWork W2070219675 @default.
- W2079751378 hasRelatedWork W2803613523 @default.
- W2079751378 hasRelatedWork W2994748025 @default.
- W2079751378 hasRelatedWork W4289813481 @default.
- W2079751378 hasRelatedWork W4378348350 @default.
- W2079751378 hasRelatedWork W2264373215 @default.
- W2079751378 hasVolume "17" @default.
- W2079751378 isParatext "false" @default.
- W2079751378 isRetracted "false" @default.
- W2079751378 magId "2079751378" @default.
- W2079751378 workType "article" @default.