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- W2079753314 abstract "Three pseudogenes for the nuclear-encoded subunit VIb of cytochrome c oxidase (COX) were isolated by screening a human genomic library with cloned human cDNA coding for COX subunit VIb. The nucleotide sequences of the pseudogenes, designated ΨCOX6b-1, ΨCOX6b-2 and ΨCOX6b-3, were determined. Pseudogene ΨCOX6b-1 bears all the hallmarks of a processed pseudogene and diverged from the parental gene after the divergence of man and cow. Alu repetitive elements were integrated into the structural sequences of the other two pseudogenes. Comparison with the human and bovine cDNA sequences encoding COX subunit Vlb suggests that ΨCOX6b-2 and ΨCOX6b-3 were formed earlier in evolution than ΨCOX6b-1. Genomic Southern analysis indicated that a few more pseudogenes for COX subunit VIb are likely to be present in the human genome. Identical nt differences with respect to the human cDNA sequence in the pseudogenes provide some clues on the evolution of the ancestral gene coding for COX subunit VIb. Tel. (31-50)632737; Fax (31-50)632606." @default.
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- W2079753314 date "1991-06-01" @default.
- W2079753314 modified "2023-10-18" @default.
- W2079753314 title "Identification of three human pseudogenes for subunit Vlb of cytochrome c oxidase: a molecular record of gene evolution" @default.
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- W2079753314 doi "https://doi.org/10.1016/0378-1119(91)90083-n" @default.
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