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• W2079753923 abstract "The potential of eugenol and of clove leaf oil, which contains a high concentration of eugenol, to induce delayed skin hypersensitivity or to elicit reactions due to pre-existing skin sensitization in man was evaluated by analysing patch-test data. Results from a total of 11,632 patch tests on eugenol itself, on various consumer products containing eugenol and/or clove leaf oil, and on fragrance blends containing eugenol and/or clove leaf oil were collected from fragrance and formulation companies. One instance of induced hypersensitivity and one instance of pre-existing sensitization were observed at eugenol patch-test concentrations of 5 X 10(-2) and 9 X 10(-2)% respectively. In both cases, subsequent patch testing showed skin responses to mixtures of eugenol and isoeugenol, but no further attempt was made to define the causative agent. The survey indicates that, at the concentrations present in consumer products, eugenol alone or as part of clove leaf oil has a very low potential either to elicit pre-existing sensitization ('elicited' reactions) or to induce hypersensitivity ('induced' reactions)." @default.
• W2079753923 created "2016-06-24" @default.
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• W2079753923 date "1983-12-01" @default.
• W2079753923 modified "2023-09-23" @default.
• W2079753923 title "Eugenol and clove leaf oil: A survey of consumer patch-test sensitization" @default.
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• W2079753923 doi "https://doi.org/10.1016/0278-6915(83)90204-1" @default.
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