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- W2079754680 abstract "An isolated perfused and ventilated lung preparation from the rat is described. After perfusion for 16–30 min the preparation responded with a reversible increase in pulmonary vascular resistence to short (3–4 min) periods of ventilation hypoxia (gas mixtures containing 2–7% O2). This pressor response to hypoxia reached a maximum 45 to 140 min after start of the perfusion. The response then declined and disappeared, whereas the preparation did still respond well to vasoactive drugs. This vulnerability of the pressor response to hypoxia is in agreement with the findings in isolated lung preparations from other species. In this preparation the disappearance of the response could be shown to be due to changes within the lungs themselves, and not to changes in the perfusate blood. None, or very slight, pressor responses to ventilation hypoxia could be elicited in preparations where platelet-poor plasma was used as a perfusate. If, however, the formed elements of the blood were added to the plasma perfusate, good responses to ventilation hypoxia appeared, provided that the addition was done during the first hour of perfusion." @default.
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- W2079754680 date "1968-01-01" @default.
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- W2079754680 title "Conditions Governing the Pressor Response to Ventilation Hypoxia in Isolated Perfused Rat Lungs" @default.
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- W2079754680 doi "https://doi.org/10.1111/j.1748-1716.1968.tb03823.x" @default.
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