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• W2079755223 abstract "Motor and nonmotor timing functions and cross-modal processing of visual-tactile signals may be linked to basal ganglia. These neural structures are thought to be dysfunctional in dystonia.To test whether cross-modal stimulation influences deficits of temporal discrimination in dystonia.Eight patients with generalized dystonia and 10 control subjects were asked to discriminate whether pairs of unimodal (tactile or visual) and cross-modal (visual and tactile) stimuli were simultaneous or sequential and, in the latter case, which stimulus preceded the other. Visual stimuli consisted of red lights and tactile stimuli of non-noxious electrical shocks. Intervals between stimuli in each pair were increased from 0 to 400 msec (in steps of 10 msec).Patients with dystonia recognized the asynchrony between the experimental stimuli and judged correctly which stimulus in a pair came first, at significantly longer intervals than did controls. Moreover, differences in performance between patients and controls were maximal for cross-modal stimuli. The defective performance of patients with dystonia in the cross-modal combinations showed a high positive correlation with the severity of symptoms.Patients with generalized dystonia present with difficulties both in timing functions and in cross-modal processing of visual-tactile stimuli." @default.
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• W2079755223 date "2003-03-11" @default.
• W2079755223 modified "2023-09-25" @default.
• W2079755223 title "Temporal discrimination of cross-modal and unimodal stimuli in generalized dystonia" @default.
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• W2079755223 doi "https://doi.org/10.1212/01.wnl.0000046528.24693.5b" @default.
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