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• W2079756201 abstract "Extracellular potassium concentration ([K+]0) was determined in neocortex of rabbits aged 1–19 days using potassium-sensitive microelectrodes. Baseline [K+]0 levels of 3 mM were obtained in some animals of all ages but levels as high as 35 mM were found in some newborn rabbits, presumably due to iatrogenic factors. This suggests that a fragility of K+ control mechanisms exists in immature cortex. Increases in [K+]0 of up to 2.6 mM occured during each interictal penicillin epileptiform discharge, were maximal in the oldest animals, and varied at different depths, being largest in deeper cortical layers. There was an inverse relationship between the baseline [K+]0 and the amount of increase during each interictal event. At resting [K+]0 levels of 10 mM or above, no detectable increase occurred during interictal or ictal epileptogenesis. Increases in [K+]0 during ictal episodes ranged from 3 to 7 mM and were larger in older animals. The rate of rise and fall of [K+]0 during interictal and ictal epileptogenesis was slower in younger animals. Ictal activity occurred in the cortex even when baseline [K+]0 levels were at leasr 20 mM." @default.
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• W2079756201 date "1974-07-01" @default.
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• W2079756201 title "Potassium activity in immature cortex" @default.
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• W2079756201 doi "https://doi.org/10.1016/0006-8993(74)90768-9" @default.
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