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- W2079756959 abstract "A systematic study of C-glycosylations of acetals related to mannose and other pyranoses was conducted. The C-5 alkoxyalkyl group provides only a modest influence on stereoselectivity. On the other hand, studies of pentopyranoses bearing alkoxy groups at C-2, C-3, and C-4 showed that the alkoxy groups exerted powerful influences on selectivity. In the case of mannose, the high alpha selectivity observed with C-mannosylation was reversed to high beta selectivity if the C-5 alkoxyalkyl group were removed. An analysis of the conformational preferences of the intermediate oxocarbenium ions, including the mannosyl cation, as well as consideration of steric effects that develop in the transition states for nucleophilic attack provide explanations for these phenomena." @default.
- W2079756959 created "2016-06-24" @default.
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- W2079756959 date "2006-03-01" @default.
- W2079756959 modified "2023-09-25" @default.
- W2079756959 title "Stereoselective <i>C</i>-Glycosylation Reactions of Pyranoses: The Conformational Preference and Reactions of the Mannosyl Cation" @default.
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- W2079756959 doi "https://doi.org/10.1021/jo0522963" @default.
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