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• W2079759972 abstract "<h2>Abstract</h2> Vitamin E (<i>α</i>-tocopherol) is a potent peroxyl radical scavenger. According to the oxidative theory of atherosclerosis, it prevents oxidation of low-density lipoprotein (LDL) and thereby lowers the risk of cardiovascular disease. It also mediates cell actions, and specifically decreases monocyte superoxide anion-production (O₂^--production), which is involved in LDL oxidation. We investigated whether <i>α</i>-tocopherol-containing LDL decreases this production in a manner dependent on the LDL <i>α</i>-tocopherol content (the <i>α</i>-tocopherol/apoB molar ratio) in human, phorbol ester-stimulated, adherent monocytes. We found that O₂^--production was inhibited by native LDL (n-LDL) in a manner highly sensitive to the increasing <i>α</i>-tocopherol content (range 4.5–8). In addition: (1) inhibition was greater when <i>α</i>-tocopherol was associated to acetylated LDL (ac-LDL), the maximal percentage of inhibition being 80% as opposed to 35% for n-LDL; (2) the <i>α</i>-tocopherol overloading of either form of LDL did not produce further inhibition; (3) the free form of <i>α</i>-tocopherol produced lower inhibition compared with the lipoprotein-associated forms; (4) inhibition was not related to the cell content of <i>α</i>-tocopherol. We propose that the cell targeting of <i>α</i>-tocopherol is crucial to the inhibition of monocyte O₂⁻-production, and thus that the role of normal LDL-<i>α</i>-tocopherol contents (range 6–8) in the prevention of atherogenic processes needs to be reexamined." @default.
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• W2079759972 date "1998-06-01" @default.
• W2079759972 modified "2023-09-24" @default.
• W2079759972 title "Monocyte superoxide production is inversely related to normal content of α-tocopherol in low-density lipoprotein" @default.
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• W2079759972 doi "https://doi.org/10.1016/s0021-9150(98)00028-8" @default.
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