FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079760143> ?p ?o ?g. }

• W2079760143 endingPage "34" @default.
• W2079760143 startingPage "28" @default.
• W2079760143 abstract "Rheumatoid arthritis (RA) is a chronic, autoimmune disease that affects primarily the joints and without proper treatment results in their progressive destruction. In addition to T-cells, B-cells play a central role in the pathogenesis of this disease. The synovial tissue is an active site of B-cell accumulation, plasma cell differentiation and in situ antibody-production in RA. As part of the complex role of B-cells in the joints and synovial membrane of RA patients, B cells secrete chemokines and cytokines and may function as antigen presenting cells. The multifaceted pathogenic function of B-cells identifies them as excellent targets for immunosuppressive therapy. B-cell targeting involves a wide spectrum of molecules, for example the B-cell antigen CD20 that allows specific and effective B-cell depletion. Another target, CD79, expressed by B-cell and plasma cell precursors is an obvious candidate that induces apoptosis as well as inhibition of B-cell receptor (BCR) activation and possibly depletion of ectopic germinal centers (GC). Inhibition of B-cell co-stimulatory molecules such as CD40, CD80/86 and ICOS, can lead to diminished B-cell activation. Moreover, anti-chemokine and anti-cytokine therapies can be efficacious in RA by the disruption of B-cell activation and autoantibody production, B-cell synovial migration and ectopic GC formation. Finally, targeting the signal transduction pathways required for proximal BCR signaling has also been found efficacious in early clinical trials in RA. Even so, some B cells inhibit immune responses, these regulatory B cells may play a part in immune regulation in patients and it is unclear what effects B cell depletion strategies have in terms of such B cell subsets. This review discusses current strategies of targeting B-cells as therapeutic candidates in the management of RA. Better insights into the pathogenic role of B-cells provide efficacious opportunities to improve both therapy and prognosis of patients with RA." @default.
• W2079760143 created "2016-06-24" @default.
• W2079760143 creator A5013332149 @default.
• W2079760143 creator A5020937342 @default.
• W2079760143 creator A5030336875 @default.
• W2079760143 creator A5050963625 @default.
• W2079760143 creator A5058671178 @default.
• W2079760143 creator A5067736962 @default.
• W2079760143 creator A5070289679 @default.
• W2079760143 date "2011-11-01" @default.
• W2079760143 modified "2023-10-07" @default.
• W2079760143 title "B-cells and their targeting in rheumatoid arthritis — Current concepts and future perspectives" @default.
• W2079760143 cites W1497102649 @default.
• W2079760143 cites W1532425407 @default.
• W2079760143 cites W1557965753 @default.
• W2079760143 cites W1578038270 @default.
• W2079760143 cites W1652932980 @default.
• W2079760143 cites W1964917126 @default.
• W2079760143 cites W1974010669 @default.
• W2079760143 cites W1975673932 @default.
• W2079760143 cites W1977271544 @default.
• W2079760143 cites W1978814302 @default.
• W2079760143 cites W1985477675 @default.
• W2079760143 cites W1994955099 @default.
• W2079760143 cites W1995386393 @default.
• W2079760143 cites W2004877600 @default.
• W2079760143 cites W2008116475 @default.
• W2079760143 cites W2008925400 @default.
• W2079760143 cites W2009074857 @default.
• W2079760143 cites W2010768033 @default.
• W2079760143 cites W2010862163 @default.
• W2079760143 cites W2024988150 @default.
• W2079760143 cites W2034782426 @default.
• W2079760143 cites W2039324671 @default.
• W2079760143 cites W2044713055 @default.
• W2079760143 cites W2045486329 @default.
• W2079760143 cites W2047662292 @default.
• W2079760143 cites W2055287053 @default.
• W2079760143 cites W2058780345 @default.
• W2079760143 cites W2068359337 @default.
• W2079760143 cites W2074051660 @default.
• W2079760143 cites W2074103250 @default.
• W2079760143 cites W2077286174 @default.
• W2079760143 cites W2078446345 @default.
• W2079760143 cites W2080942943 @default.
• W2079760143 cites W2086113234 @default.
• W2079760143 cites W2086734015 @default.
• W2079760143 cites W2088328410 @default.
• W2079760143 cites W2088593344 @default.
• W2079760143 cites W2091753305 @default.
• W2079760143 cites W2100446659 @default.
• W2079760143 cites W2105594762 @default.
• W2079760143 cites W2105821343 @default.
• W2079760143 cites W2106841955 @default.
• W2079760143 cites W2107073924 @default.
• W2079760143 cites W2107821023 @default.
• W2079760143 cites W2107894877 @default.
• W2079760143 cites W2112844656 @default.
• W2079760143 cites W2115124776 @default.
• W2079760143 cites W2127956619 @default.
• W2079760143 cites W2128952811 @default.
• W2079760143 cites W2131457901 @default.
• W2079760143 cites W2134264204 @default.
• W2079760143 cites W2137157133 @default.
• W2079760143 cites W2137664028 @default.
• W2079760143 cites W2143666663 @default.
• W2079760143 cites W2147422161 @default.
• W2079760143 cites W2155466629 @default.
• W2079760143 cites W2156787360 @default.
• W2079760143 cites W2157130851 @default.
• W2079760143 cites W2167800322 @default.
• W2079760143 cites W2170143249 @default.
• W2079760143 cites W2333785992 @default.
• W2079760143 cites W4210968471 @default.
• W2079760143 doi "https://doi.org/10.1016/j.autrev.2011.06.010" @default.
• W2079760143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21777703" @default.
• W2079760143 hasPublicationYear "2011" @default.
• W2079760143 type Work @default.
• W2079760143 sameAs 2079760143 @default.
• W2079760143 citedByCount "84" @default.
• W2079760143 countsByYear W20797601432012 @default.
• W2079760143 countsByYear W20797601432013 @default.
• W2079760143 countsByYear W20797601432014 @default.
• W2079760143 countsByYear W20797601432015 @default.
• W2079760143 countsByYear W20797601432016 @default.
• W2079760143 countsByYear W20797601432017 @default.
• W2079760143 countsByYear W20797601432018 @default.
• W2079760143 countsByYear W20797601432019 @default.
• W2079760143 countsByYear W20797601432020 @default.
• W2079760143 countsByYear W20797601432021 @default.
• W2079760143 countsByYear W20797601432022 @default.
• W2079760143 countsByYear W20797601432023 @default.
• W2079760143 crossrefType "journal-article" @default.
• W2079760143 hasAuthorship W2079760143A5013332149 @default.
• W2079760143 hasAuthorship W2079760143A5020937342 @default.
• W2079760143 hasAuthorship W2079760143A5030336875 @default.
• W2079760143 hasAuthorship W2079760143A5050963625 @default.
• W2079760143 hasAuthorship W2079760143A5058671178 @default.

• next