Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079761285> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079761285 endingPage "323" @default.
- W2079761285 startingPage "319" @default.
- W2079761285 abstract "Advanced glycation end products (AGEs) are thought to be responsible for some complications of diabetes mellitus (DM), including microangiopathy. Plasma serotonin is increased in diabetes mellitus patients, and this increase is related, at least in part, to platelet hyperfunction. In order to clarify the relationship between advanced glycation end products, serotonin, and thrombotic complications in diabetes mellitus patients, we examined the effect of advanced glycation end products on serotonin-induced platelet aggregation. In diabetic patients, although serotonin-induced platelet aggregation was enhanced with an increase in serum-advanced glycation end products, there was no correlation between platelet aggregation and either hemoglobin A1c or fasting blood sugar. To examine the direct effect of advanced glycation end products on platelet aggregation, we prepared advanced glycation end products by in vitro incubation of human albumin with glucose (250 mM) at 37 degrees C for 8 weeks. Serotonin-induced platelet aggregation was dose-dependently increased by advanced glycation end products. Adenosine diphosphate-induced platelet aggregation also was increased by advanced glycation end products, but this increment was diminished by addition of sarpogrelate, a selective serotonin receptor antagonist. These results suggest that advanced glycation end products enhance platelet aggregation through the serotonin receptor, and perhaps influencing the development of thrombotic complications in diabetic patients." @default.
- W2079761285 created "2016-06-24" @default.
- W2079761285 creator A5022166469 @default.
- W2079761285 creator A5024889079 @default.
- W2079761285 creator A5036949502 @default.
- W2079761285 creator A5052161758 @default.
- W2079761285 creator A5063924625 @default.
- W2079761285 date "2002-09-01" @default.
- W2079761285 modified "2023-10-17" @default.
- W2079761285 title "Enhancing effect of advanced glycation end products on serotonin-induced platelet aggregation in patients with diabetes mellitus" @default.
- W2079761285 cites W1869787745 @default.
- W2079761285 cites W1964124333 @default.
- W2079761285 cites W1991494422 @default.
- W2079761285 cites W1997349856 @default.
- W2079761285 cites W1998614770 @default.
- W2079761285 cites W2053900103 @default.
- W2079761285 cites W2058597871 @default.
- W2079761285 cites W2060925799 @default.
- W2079761285 cites W2065801590 @default.
- W2079761285 cites W2069942321 @default.
- W2079761285 cites W2097575936 @default.
- W2079761285 cites W2123090820 @default.
- W2079761285 cites W2153609395 @default.
- W2079761285 cites W2164553737 @default.
- W2079761285 cites W2165519954 @default.
- W2079761285 cites W2315898913 @default.
- W2079761285 cites W2317016578 @default.
- W2079761285 cites W4240397872 @default.
- W2079761285 cites W4230510874 @default.
- W2079761285 doi "https://doi.org/10.1016/s0049-3848(02)00348-1" @default.
- W2079761285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12565718" @default.
- W2079761285 hasPublicationYear "2002" @default.
- W2079761285 type Work @default.
- W2079761285 sameAs 2079761285 @default.
- W2079761285 citedByCount "58" @default.
- W2079761285 countsByYear W20797612852012 @default.
- W2079761285 countsByYear W20797612852013 @default.
- W2079761285 countsByYear W20797612852014 @default.
- W2079761285 countsByYear W20797612852015 @default.
- W2079761285 countsByYear W20797612852016 @default.
- W2079761285 countsByYear W20797612852017 @default.
- W2079761285 countsByYear W20797612852018 @default.
- W2079761285 countsByYear W20797612852019 @default.
- W2079761285 countsByYear W20797612852020 @default.
- W2079761285 countsByYear W20797612852021 @default.
- W2079761285 countsByYear W20797612852022 @default.
- W2079761285 crossrefType "journal-article" @default.
- W2079761285 hasAuthorship W2079761285A5022166469 @default.
- W2079761285 hasAuthorship W2079761285A5024889079 @default.
- W2079761285 hasAuthorship W2079761285A5036949502 @default.
- W2079761285 hasAuthorship W2079761285A5052161758 @default.
- W2079761285 hasAuthorship W2079761285A5063924625 @default.
- W2079761285 hasConcept C126322002 @default.
- W2079761285 hasConcept C134018914 @default.
- W2079761285 hasConcept C147990577 @default.
- W2079761285 hasConcept C170493617 @default.
- W2079761285 hasConcept C185592680 @default.
- W2079761285 hasConcept C2775864247 @default.
- W2079761285 hasConcept C2776997535 @default.
- W2079761285 hasConcept C555293320 @default.
- W2079761285 hasConcept C71924100 @default.
- W2079761285 hasConcept C89560881 @default.
- W2079761285 hasConceptScore W2079761285C126322002 @default.
- W2079761285 hasConceptScore W2079761285C134018914 @default.
- W2079761285 hasConceptScore W2079761285C147990577 @default.
- W2079761285 hasConceptScore W2079761285C170493617 @default.
- W2079761285 hasConceptScore W2079761285C185592680 @default.
- W2079761285 hasConceptScore W2079761285C2775864247 @default.
- W2079761285 hasConceptScore W2079761285C2776997535 @default.
- W2079761285 hasConceptScore W2079761285C555293320 @default.
- W2079761285 hasConceptScore W2079761285C71924100 @default.
- W2079761285 hasConceptScore W2079761285C89560881 @default.
- W2079761285 hasIssue "6" @default.
- W2079761285 hasLocation W20797612851 @default.
- W2079761285 hasLocation W20797612852 @default.
- W2079761285 hasOpenAccess W2079761285 @default.
- W2079761285 hasPrimaryLocation W20797612851 @default.
- W2079761285 hasRelatedWork W1522849455 @default.
- W2079761285 hasRelatedWork W1971453675 @default.
- W2079761285 hasRelatedWork W2027411819 @default.
- W2079761285 hasRelatedWork W2027622212 @default.
- W2079761285 hasRelatedWork W2050824222 @default.
- W2079761285 hasRelatedWork W2055572014 @default.
- W2079761285 hasRelatedWork W2060872667 @default.
- W2079761285 hasRelatedWork W2107899720 @default.
- W2079761285 hasRelatedWork W2128286595 @default.
- W2079761285 hasRelatedWork W4241062279 @default.
- W2079761285 hasVolume "107" @default.
- W2079761285 isParatext "false" @default.
- W2079761285 isRetracted "false" @default.
- W2079761285 magId "2079761285" @default.
- W2079761285 workType "article" @default.