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- W2079762015 abstract "Background: The role of mechanical factors in OA pathogenesis is undisputed, but how these factors drive the processes that lead to joint disease is unknown. What is clear is that OA is not simply a disease of cartilage attrition as a result of abnormal or repetitive wearing of the surfaces, but that it requires activation of pathways that lead to expression of degradative enzymes, which break down the matrix. We have established a murine surgical model of OA, that causes destabilization of the medial meniscus (DMM) and which produces robust cartilage degeneration within 8–12 weeks of surgery. The aim of this study was to examine the early expression of inflammatory genes in the joints of OA mice and to assess the influence of joint loading on gene expression and the development of OA." @default.
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- W2079762015 date "2010-03-22" @default.
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- W2079762015 title "Concurrent Oral 11 - Osteoarthritis [OP73-OP78]: OP73. Mechanical Load Drives Inflammatory Gene Expression and Disease in Murine OA" @default.
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- W2079762015 doi "https://doi.org/10.1093/rheumatology/keq711" @default.
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