Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079763005> ?p ?o ?g. }
- W2079763005 endingPage "173" @default.
- W2079763005 startingPage "167" @default.
- W2079763005 abstract "Genomic variation in the regulatory region of the serotonin (5-HT) 2A receptor gene (HTR2A) may contribute to altered levels of 5-HT2A receptor and to psychiatric disease.Frequency and linkage disequilibrium (LD) were determined for promoter single nucleotide polymorphisms (SNPs) -1438A/G, -1420C/T, and -783A/G in 156 subjects. Functional relevance of -1438A/G and -783A/G was assayed in vitro using a luciferase reporter assay and ex vivo using quantitative real time polymerase chain reaction in a set of human fibroblast cell lines.Significant LD was observed between SNPs -1438A/G and -783A/G. In vitro assays showed no significant differences in promoter activity between the A- and G-allele of -1438 locus when expressed with the major alleles at -1420C/T and -783A/G; however, when the minor allele G at -783 was expressed with G-allele at -1438, promoter activity was significantly decreased. 5-HT2A receptor mRNA expression in human fibroblast cell lines confirmed that -783A/G polymorphism significantly modified the effects of -1438A/G SNP.Our results demonstrate that SNP -783A/G modifies the effects of the major SNP -1438A/G. Future studies examining the association of -1438A/G polymorphism with diseases and 5-HT2A receptor expression analyses should account for this epistasis." @default.
- W2079763005 created "2016-06-24" @default.
- W2079763005 creator A5029185626 @default.
- W2079763005 creator A5029968735 @default.
- W2079763005 creator A5068395491 @default.
- W2079763005 creator A5087160785 @default.
- W2079763005 creator A5087737932 @default.
- W2079763005 date "2007-01-01" @default.
- W2079763005 modified "2023-10-16" @default.
- W2079763005 title "Polymorphisms in the Regulatory Region of the Human Serotonin 5-HT 2A Receptor Gene (HTR2A) Influence Gene Expression" @default.
- W2079763005 cites W143404125 @default.
- W2079763005 cites W1659444689 @default.
- W2079763005 cites W1899399637 @default.
- W2079763005 cites W1964574547 @default.
- W2079763005 cites W1968884554 @default.
- W2079763005 cites W1977277134 @default.
- W2079763005 cites W1983459688 @default.
- W2079763005 cites W1986007275 @default.
- W2079763005 cites W1990928272 @default.
- W2079763005 cites W1993854956 @default.
- W2079763005 cites W1998826858 @default.
- W2079763005 cites W1999029753 @default.
- W2079763005 cites W1999265734 @default.
- W2079763005 cites W2001059064 @default.
- W2079763005 cites W2006600898 @default.
- W2079763005 cites W2006833690 @default.
- W2079763005 cites W2007091244 @default.
- W2079763005 cites W2010894744 @default.
- W2079763005 cites W2013029069 @default.
- W2079763005 cites W2015599737 @default.
- W2079763005 cites W2022455207 @default.
- W2079763005 cites W2027826213 @default.
- W2079763005 cites W2036315232 @default.
- W2079763005 cites W2041974250 @default.
- W2079763005 cites W2044852143 @default.
- W2079763005 cites W2045933553 @default.
- W2079763005 cites W2050763807 @default.
- W2079763005 cites W2054179546 @default.
- W2079763005 cites W2056459965 @default.
- W2079763005 cites W2056674018 @default.
- W2079763005 cites W2058472215 @default.
- W2079763005 cites W2060181859 @default.
- W2079763005 cites W2067915668 @default.
- W2079763005 cites W2068160148 @default.
- W2079763005 cites W2070294663 @default.
- W2079763005 cites W2075903380 @default.
- W2079763005 cites W2080992988 @default.
- W2079763005 cites W2085568875 @default.
- W2079763005 cites W2085672566 @default.
- W2079763005 cites W2094670444 @default.
- W2079763005 cites W2102328435 @default.
- W2079763005 cites W2103951395 @default.
- W2079763005 cites W2111751310 @default.
- W2079763005 cites W2116816790 @default.
- W2079763005 cites W2130153674 @default.
- W2079763005 cites W2134560546 @default.
- W2079763005 cites W2140425130 @default.
- W2079763005 cites W2144665117 @default.
- W2079763005 cites W2302121233 @default.
- W2079763005 cites W2330988369 @default.
- W2079763005 cites W4242577247 @default.
- W2079763005 cites W4254753097 @default.
- W2079763005 doi "https://doi.org/10.1016/j.biopsych.2005.12.018" @default.
- W2079763005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16697352" @default.
- W2079763005 hasPublicationYear "2007" @default.
- W2079763005 type Work @default.
- W2079763005 sameAs 2079763005 @default.
- W2079763005 citedByCount "118" @default.
- W2079763005 countsByYear W20797630052012 @default.
- W2079763005 countsByYear W20797630052013 @default.
- W2079763005 countsByYear W20797630052014 @default.
- W2079763005 countsByYear W20797630052015 @default.
- W2079763005 countsByYear W20797630052016 @default.
- W2079763005 countsByYear W20797630052017 @default.
- W2079763005 countsByYear W20797630052018 @default.
- W2079763005 countsByYear W20797630052019 @default.
- W2079763005 countsByYear W20797630052020 @default.
- W2079763005 countsByYear W20797630052022 @default.
- W2079763005 countsByYear W20797630052023 @default.
- W2079763005 crossrefType "journal-article" @default.
- W2079763005 hasAuthorship W2079763005A5029185626 @default.
- W2079763005 hasAuthorship W2079763005A5029968735 @default.
- W2079763005 hasAuthorship W2079763005A5068395491 @default.
- W2079763005 hasAuthorship W2079763005A5087160785 @default.
- W2079763005 hasAuthorship W2079763005A5087737932 @default.
- W2079763005 hasConcept C104317684 @default.
- W2079763005 hasConcept C135763542 @default.
- W2079763005 hasConcept C139275648 @default.
- W2079763005 hasConcept C150194340 @default.
- W2079763005 hasConcept C153209595 @default.
- W2079763005 hasConcept C153911025 @default.
- W2079763005 hasConcept C170493617 @default.
- W2079763005 hasConcept C180754005 @default.
- W2079763005 hasConcept C35605836 @default.
- W2079763005 hasConcept C54355233 @default.
- W2079763005 hasConcept C84597430 @default.
- W2079763005 hasConcept C86803240 @default.
- W2079763005 hasConceptScore W2079763005C104317684 @default.