Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079764479> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2079764479 endingPage "122" @default.
- W2079764479 startingPage "117" @default.
- W2079764479 abstract "Under the activation of insulin receptors, glucose transporter 4 (Glut4) translocation is regulated by two signal transduction pathways. These pathways are the PI 3-kinase-dependent pathway and the CAP/TC10 pathway. The adaptor protein Rap guanine exchange factor 1 (RAPGEF1) also known as C3G is a component of the CAP/TC10 pathway. Defects in the RAPGEF1 protein may contribute to insulin resistance and type 2 diabetes. Recently, the RAPGEF1 gene was suggested to be involved in the development of type 2 diabetes by FUSION study. To investigate this association in the Korean population, we sequenced the RAPGEF1 gene in 24 unrelated individuals and identified 39 sequence variants. Eleven single nucleotide polymorphisms (SNPs) were selected and genotyped in 1122 Korean patients with type 2 diabetes. There were 1138 non-diabetic controls. Using a logistic regression analysis, a significant association was found between SNP rs11243444 in the RAPGEF1 gene and type 2 diabetes [OR = 0.490 (95% CI 0.296–0.813), p = 0.006] in the recessive model, leading the protective effect of the GG genotype on the disease development. The present study examines genetic polymorphisms in the RAPGEF1 gene, and the positive association between one polymorphism and type 2 diabetes in the Korean population." @default.
- W2079764479 created "2016-06-24" @default.
- W2079764479 creator A5025651710 @default.
- W2079764479 creator A5030510471 @default.
- W2079764479 creator A5039106969 @default.
- W2079764479 creator A5041763872 @default.
- W2079764479 creator A5043945362 @default.
- W2079764479 creator A5050460445 @default.
- W2079764479 creator A5053690881 @default.
- W2079764479 creator A5062848451 @default.
- W2079764479 creator A5075460945 @default.
- W2079764479 date "2009-05-01" @default.
- W2079764479 modified "2023-10-14" @default.
- W2079764479 title "RAPGEF1 gene variants associated with type 2 diabetes in the Korean population" @default.
- W2079764479 cites W1976907183 @default.
- W2079764479 cites W1980603442 @default.
- W2079764479 cites W1988840384 @default.
- W2079764479 cites W1990592352 @default.
- W2079764479 cites W2004767178 @default.
- W2079764479 cites W2033429522 @default.
- W2079764479 cites W2040309911 @default.
- W2079764479 cites W2089127518 @default.
- W2079764479 cites W2095252238 @default.
- W2079764479 cites W2120753520 @default.
- W2079764479 cites W2127815800 @default.
- W2079764479 cites W2133790985 @default.
- W2079764479 cites W2161404841 @default.
- W2079764479 cites W2161573035 @default.
- W2079764479 cites W2162530578 @default.
- W2079764479 doi "https://doi.org/10.1016/j.diabres.2009.02.019" @default.
- W2079764479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19297053" @default.
- W2079764479 hasPublicationYear "2009" @default.
- W2079764479 type Work @default.
- W2079764479 sameAs 2079764479 @default.
- W2079764479 citedByCount "16" @default.
- W2079764479 countsByYear W20797644792012 @default.
- W2079764479 countsByYear W20797644792015 @default.
- W2079764479 countsByYear W20797644792016 @default.
- W2079764479 countsByYear W20797644792017 @default.
- W2079764479 countsByYear W20797644792018 @default.
- W2079764479 countsByYear W20797644792021 @default.
- W2079764479 countsByYear W20797644792022 @default.
- W2079764479 crossrefType "journal-article" @default.
- W2079764479 hasAuthorship W2079764479A5025651710 @default.
- W2079764479 hasAuthorship W2079764479A5030510471 @default.
- W2079764479 hasAuthorship W2079764479A5039106969 @default.
- W2079764479 hasAuthorship W2079764479A5041763872 @default.
- W2079764479 hasAuthorship W2079764479A5043945362 @default.
- W2079764479 hasAuthorship W2079764479A5050460445 @default.
- W2079764479 hasAuthorship W2079764479A5053690881 @default.
- W2079764479 hasAuthorship W2079764479A5062848451 @default.
- W2079764479 hasAuthorship W2079764479A5075460945 @default.
- W2079764479 hasConcept C104317684 @default.
- W2079764479 hasConcept C134018914 @default.
- W2079764479 hasConcept C135763542 @default.
- W2079764479 hasConcept C139275648 @default.
- W2079764479 hasConcept C149737253 @default.
- W2079764479 hasConcept C153209595 @default.
- W2079764479 hasConcept C2777180221 @default.
- W2079764479 hasConcept C2908647359 @default.
- W2079764479 hasConcept C54355233 @default.
- W2079764479 hasConcept C555293320 @default.
- W2079764479 hasConcept C71924100 @default.
- W2079764479 hasConcept C86803240 @default.
- W2079764479 hasConcept C99454951 @default.
- W2079764479 hasConceptScore W2079764479C104317684 @default.
- W2079764479 hasConceptScore W2079764479C134018914 @default.
- W2079764479 hasConceptScore W2079764479C135763542 @default.
- W2079764479 hasConceptScore W2079764479C139275648 @default.
- W2079764479 hasConceptScore W2079764479C149737253 @default.
- W2079764479 hasConceptScore W2079764479C153209595 @default.
- W2079764479 hasConceptScore W2079764479C2777180221 @default.
- W2079764479 hasConceptScore W2079764479C2908647359 @default.
- W2079764479 hasConceptScore W2079764479C54355233 @default.
- W2079764479 hasConceptScore W2079764479C555293320 @default.
- W2079764479 hasConceptScore W2079764479C71924100 @default.
- W2079764479 hasConceptScore W2079764479C86803240 @default.
- W2079764479 hasConceptScore W2079764479C99454951 @default.
- W2079764479 hasIssue "2" @default.
- W2079764479 hasLocation W20797644791 @default.
- W2079764479 hasLocation W20797644792 @default.
- W2079764479 hasOpenAccess W2079764479 @default.
- W2079764479 hasPrimaryLocation W20797644791 @default.
- W2079764479 hasRelatedWork W2056355462 @default.
- W2079764479 hasRelatedWork W2107074164 @default.
- W2079764479 hasRelatedWork W2161110446 @default.
- W2079764479 hasRelatedWork W2283861756 @default.
- W2079764479 hasRelatedWork W2358154819 @default.
- W2079764479 hasRelatedWork W2368205087 @default.
- W2079764479 hasRelatedWork W2790470715 @default.
- W2079764479 hasRelatedWork W3030331178 @default.
- W2079764479 hasRelatedWork W3177672991 @default.
- W2079764479 hasRelatedWork W4323251038 @default.
- W2079764479 hasVolume "84" @default.
- W2079764479 isParatext "false" @default.
- W2079764479 isRetracted "false" @default.
- W2079764479 magId "2079764479" @default.
- W2079764479 workType "article" @default.