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- W2079764755 abstract "Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequencing to distinguish among the allelic variants. While such methods are extremely accurate as well as quantitative in determining the number of T residues in the poly-T region, the process can be cumbersome, time consuming and expensive to employ in routine laboratories. To this end, we have developed a quick and simple method to isotype the human TOMM40 variable length polymorphism using a PCR- and restriction digest-based approach, enabling rapid genotyping of TOMM40 variants." @default.
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- W2079764755 date "2012-11-22" @default.
- W2079764755 modified "2023-09-25" @default.
- W2079764755 title "Isotyping the Human TOMM40 Variable-Length Polymorphism by Gene Amplification and Restriction Digest" @default.
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- W2079764755 doi "https://doi.org/10.2174/156720512804142921" @default.
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