FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079764967> ?p ?o ?g. }

• W2079764967 endingPage "587" @default.
• W2079764967 startingPage "577" @default.
• W2079764967 abstract "The neurodegenerative disease amyotrophic lateral sclerosis (ALS) results from the progressive loss of motoneurons, leading to death in a few years. Ciliary neurotrophic factor (CNTF), which decreases naturally occurring and axotomy-induced cell death, may result in slowing of motoneuron loss and has been evaluated as a treatment for ALS. Effective administration of this protein to motoneurons may be hampered by the exceedingly short half-life of CNTF, and the inability to deliver effective concentration into the central nervous system after systemic administration in vivo. The constitutive release of CNTF from genetically engineered cells may represent a solution to this delivery problem. In this work, baby hamster kidney (BHK) cells stably tranfected with a chimeric plasmid construct containing the gene for human or mouse CNTF were encapsulated in polymer fibers, which prevents immune rejection and allow long-term survival of the transplanted cells. In vitro bioassays show that the encapsulated transfected cells release bioactive CNTF. In vivo, systemic delivery of human and mouse CNTF from encapsulated cells was observed to rescue 26 and 27% more facial motoneurons, respectively, as compared to capsules containing parent BHK cells 1 wk postaxotomy in neonatal rats. With local application of CNTF on the nerve stump and by systemic delivery through repeated subcutaneous injections, 15 and 13% more rescue effects were observed. These data illustrate the potential of using encapsulated genetically engineered cells to continuously release CNTF to slow down motoneuron degeneration following axotomy and suggest that encapsulated cell delivery of neurotrophic factors may provide a general method for effective administration of therapeutic proteins for the treatment of neurodegenerative diseases." @default.
• W2079764967 created "2016-06-24" @default.
• W2079764967 creator A5001356149 @default.
• W2079764967 creator A5009387400 @default.
• W2079764967 creator A5012078698 @default.
• W2079764967 creator A5042725801 @default.
• W2079764967 creator A5050667995 @default.
• W2079764967 creator A5077856861 @default.
• W2079764967 creator A5087753311 @default.
• W2079764967 date "1996-10-01" @default.
• W2079764967 modified "2023-09-23" @default.
• W2079764967 title "Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF" @default.
• W2079764967 cites W1516120828 @default.
• W2079764967 cites W1517125774 @default.
• W2079764967 cites W1533666462 @default.
• W2079764967 cites W1608420739 @default.
• W2079764967 cites W1817338119 @default.
• W2079764967 cites W1923790426 @default.
• W2079764967 cites W1932913848 @default.
• W2079764967 cites W1966697408 @default.
• W2079764967 cites W1968122470 @default.
• W2079764967 cites W1972531020 @default.
• W2079764967 cites W1973505460 @default.
• W2079764967 cites W1976857475 @default.
• W2079764967 cites W1981238340 @default.
• W2079764967 cites W1989434542 @default.
• W2079764967 cites W1990590034 @default.
• W2079764967 cites W1993715950 @default.
• W2079764967 cites W1993770832 @default.
• W2079764967 cites W1994365433 @default.
• W2079764967 cites W1994452959 @default.
• W2079764967 cites W2002367555 @default.
• W2079764967 cites W2006077413 @default.
• W2079764967 cites W2007744878 @default.
• W2079764967 cites W2008291157 @default.
• W2079764967 cites W2008530919 @default.
• W2079764967 cites W2015041369 @default.
• W2079764967 cites W2018068734 @default.
• W2079764967 cites W2020333978 @default.
• W2079764967 cites W2029128430 @default.
• W2079764967 cites W203023652 @default.
• W2079764967 cites W2031675916 @default.
• W2079764967 cites W2033374103 @default.
• W2079764967 cites W2035781629 @default.
• W2079764967 cites W2037957091 @default.
• W2079764967 cites W2040286934 @default.
• W2079764967 cites W2043776713 @default.
• W2079764967 cites W2046739492 @default.
• W2079764967 cites W2048465320 @default.
• W2079764967 cites W2050304234 @default.
• W2079764967 cites W2056041896 @default.
• W2079764967 cites W2057835832 @default.
• W2079764967 cites W2063664890 @default.
• W2079764967 cites W2076193941 @default.
• W2079764967 cites W2078119356 @default.
• W2079764967 cites W2080173984 @default.
• W2079764967 cites W2082995803 @default.
• W2079764967 cites W2088162707 @default.
• W2079764967 cites W2088986997 @default.
• W2079764967 cites W2093749821 @default.
• W2079764967 cites W2095454466 @default.
• W2079764967 cites W2142761289 @default.
• W2079764967 cites W2148240710 @default.
• W2079764967 cites W2151903320 @default.
• W2079764967 cites W2168731670 @default.
• W2079764967 cites W68229241 @default.
• W2079764967 doi "https://doi.org/10.1016/0963-6897(96)00081-4" @default.
• W2079764967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8889216" @default.
• W2079764967 hasPublicationYear "1996" @default.
• W2079764967 type Work @default.
• W2079764967 sameAs 2079764967 @default.
• W2079764967 citedByCount "36" @default.
• W2079764967 countsByYear W20797649672012 @default.
• W2079764967 countsByYear W20797649672013 @default.
• W2079764967 countsByYear W20797649672014 @default.
• W2079764967 countsByYear W20797649672018 @default.
• W2079764967 crossrefType "journal-article" @default.
• W2079764967 hasAuthorship W2079764967A5001356149 @default.
• W2079764967 hasAuthorship W2079764967A5009387400 @default.
• W2079764967 hasAuthorship W2079764967A5012078698 @default.
• W2079764967 hasAuthorship W2079764967A5042725801 @default.
• W2079764967 hasAuthorship W2079764967A5050667995 @default.
• W2079764967 hasAuthorship W2079764967A5077856861 @default.
• W2079764967 hasAuthorship W2079764967A5087753311 @default.
• W2079764967 hasConcept C104317684 @default.
• W2079764967 hasConcept C1491633281 @default.
• W2079764967 hasConcept C160539049 @default.
• W2079764967 hasConcept C170493617 @default.
• W2079764967 hasConcept C171056886 @default.
• W2079764967 hasConcept C185592680 @default.
• W2079764967 hasConcept C190283241 @default.
• W2079764967 hasConcept C2779683492 @default.
• W2079764967 hasConcept C3019111730 @default.
• W2079764967 hasConcept C31573885 @default.
• W2079764967 hasConcept C51456166 @default.
• W2079764967 hasConcept C55493867 @default.
• W2079764967 hasConcept C68710172 @default.
• W2079764967 hasConcept C86803240 @default.

• next