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- W2079771195 endingPage "1319" @default.
- W2079771195 startingPage "1311" @default.
- W2079771195 abstract "The Wnt/Frizzled signaling pathway plays multiple functions in animal development and, when deregulated, in human disease. The G-protein coupled receptor (GPCR) Frizzled and its cognate heterotrimeric Gi/o proteins initiate the intracellular signaling cascades resulting in cell fate determination and polarization. In this review, we summarize the knowledge on the ligand recognition, biochemistry, modifications and interacting partners of the Frizzled proteins viewed as GPCRs. We also discuss the effectors of the heterotrimeric Go protein in Frizzled signaling. One group of these effectors is represented by small GTPases of the Rab family, which amplify the initial Wnt/Frizzled signal. Another effector is the negative regulator of Wnt signaling Axin, which becomes deactivated in response to Go action. The discovery of the GPCR properties of Frizzled receptors not only provides mechanistic understanding to their signaling pathways, but also paves new avenues for the drug discovery efforts." @default.
- W2079771195 created "2016-06-24" @default.
- W2079771195 creator A5038733212 @default.
- W2079771195 creator A5039705040 @default.
- W2079771195 creator A5071908777 @default.
- W2079771195 creator A5087206207 @default.
- W2079771195 date "2011-11-01" @default.
- W2079771195 modified "2023-10-17" @default.
- W2079771195 title "Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets" @default.
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