Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079772279> ?p ?o ?g. }
- W2079772279 endingPage "1365" @default.
- W2079772279 startingPage "1359" @default.
- W2079772279 abstract "G72/G30 is a primate-specific locus that has been repeatedly implicated as a risk factor in genetic studies of schizophrenia. The function of the longest G72 splice variant (LG72 protein) encoded by this locus is not fully understood. To investigate the role of the LG72 protein in vivo, we have generated transgenic (G72Tg) mice carrying the G72/G30 locus that exhibit schizophrenia-like symptoms. We investigated protein expression alterations in the cerebella of G72Tg compared to wild type (WT) mice using a proteomics approach based on in vivo(15)N metabolic labeling and quantitative mass spectrometry (MS). Our data revealed expression level differences of proteins involved in myelin-related processes, oxidative stress and mitochondrial function. Furthermore, in silico pathway analyses suggested common regulators and targets for the observed protein alterations. Our work sheds light on the functional role of the LG72 protein and pinpoints molecular correlates of schizophrenia-like behavior." @default.
- W2079772279 created "2016-06-24" @default.
- W2079772279 creator A5002047730 @default.
- W2079772279 creator A5026960357 @default.
- W2079772279 creator A5033763262 @default.
- W2079772279 creator A5039802710 @default.
- W2079772279 creator A5080063862 @default.
- W2079772279 date "2012-10-01" @default.
- W2079772279 modified "2023-10-16" @default.
- W2079772279 title "Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model" @default.
- W2079772279 cites W1542898773 @default.
- W2079772279 cites W1546433789 @default.
- W2079772279 cites W1966889866 @default.
- W2079772279 cites W1968763887 @default.
- W2079772279 cites W1972358546 @default.
- W2079772279 cites W1974446242 @default.
- W2079772279 cites W1984526928 @default.
- W2079772279 cites W1985438653 @default.
- W2079772279 cites W1985495387 @default.
- W2079772279 cites W1985924246 @default.
- W2079772279 cites W1990299806 @default.
- W2079772279 cites W2004340733 @default.
- W2079772279 cites W2015045750 @default.
- W2079772279 cites W2019462766 @default.
- W2079772279 cites W2021813448 @default.
- W2079772279 cites W2022001355 @default.
- W2079772279 cites W2027842970 @default.
- W2079772279 cites W2030548279 @default.
- W2079772279 cites W2037238692 @default.
- W2079772279 cites W2062533676 @default.
- W2079772279 cites W2068787204 @default.
- W2079772279 cites W2069125243 @default.
- W2079772279 cites W2069705529 @default.
- W2079772279 cites W2071697059 @default.
- W2079772279 cites W2072859446 @default.
- W2079772279 cites W2079220045 @default.
- W2079772279 cites W2079590167 @default.
- W2079772279 cites W2084538239 @default.
- W2079772279 cites W2085401189 @default.
- W2079772279 cites W2087877049 @default.
- W2079772279 cites W2088720667 @default.
- W2079772279 cites W2091960711 @default.
- W2079772279 cites W2100071020 @default.
- W2079772279 cites W2109629603 @default.
- W2079772279 cites W2110790178 @default.
- W2079772279 cites W2145993791 @default.
- W2079772279 cites W2156206992 @default.
- W2079772279 cites W2158329357 @default.
- W2079772279 cites W2169265073 @default.
- W2079772279 cites W2171686853 @default.
- W2079772279 cites W2407084435 @default.
- W2079772279 cites W4238581030 @default.
- W2079772279 cites W4251169171 @default.
- W2079772279 doi "https://doi.org/10.1016/j.jpsychires.2012.07.004" @default.
- W2079772279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22884423" @default.
- W2079772279 hasPublicationYear "2012" @default.
- W2079772279 type Work @default.
- W2079772279 sameAs 2079772279 @default.
- W2079772279 citedByCount "30" @default.
- W2079772279 countsByYear W20797722792012 @default.
- W2079772279 countsByYear W20797722792013 @default.
- W2079772279 countsByYear W20797722792014 @default.
- W2079772279 countsByYear W20797722792015 @default.
- W2079772279 countsByYear W20797722792016 @default.
- W2079772279 countsByYear W20797722792017 @default.
- W2079772279 countsByYear W20797722792019 @default.
- W2079772279 countsByYear W20797722792020 @default.
- W2079772279 countsByYear W20797722792021 @default.
- W2079772279 countsByYear W20797722792022 @default.
- W2079772279 crossrefType "journal-article" @default.
- W2079772279 hasAuthorship W2079772279A5002047730 @default.
- W2079772279 hasAuthorship W2079772279A5026960357 @default.
- W2079772279 hasAuthorship W2079772279A5033763262 @default.
- W2079772279 hasAuthorship W2079772279A5039802710 @default.
- W2079772279 hasAuthorship W2079772279A5080063862 @default.
- W2079772279 hasConcept C102230213 @default.
- W2079772279 hasConcept C104317684 @default.
- W2079772279 hasConcept C141035611 @default.
- W2079772279 hasConcept C153911025 @default.
- W2079772279 hasConcept C207001950 @default.
- W2079772279 hasConcept C2776151105 @default.
- W2079772279 hasConcept C46111723 @default.
- W2079772279 hasConcept C54355233 @default.
- W2079772279 hasConcept C55493867 @default.
- W2079772279 hasConcept C84597430 @default.
- W2079772279 hasConcept C86803240 @default.
- W2079772279 hasConceptScore W2079772279C102230213 @default.
- W2079772279 hasConceptScore W2079772279C104317684 @default.
- W2079772279 hasConceptScore W2079772279C141035611 @default.
- W2079772279 hasConceptScore W2079772279C153911025 @default.
- W2079772279 hasConceptScore W2079772279C207001950 @default.
- W2079772279 hasConceptScore W2079772279C2776151105 @default.
- W2079772279 hasConceptScore W2079772279C46111723 @default.
- W2079772279 hasConceptScore W2079772279C54355233 @default.
- W2079772279 hasConceptScore W2079772279C55493867 @default.
- W2079772279 hasConceptScore W2079772279C84597430 @default.
- W2079772279 hasConceptScore W2079772279C86803240 @default.
- W2079772279 hasIssue "10" @default.